{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:48:08Z","timestamp":1772646488712,"version":"3.50.1"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215119001130_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Parotid gland carcinoma is a rare and complicated histopathological classification. Therefore, assembling a sufficient number of cases with long-term outcomes in a single institute can present a challenge.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001130_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>The medical records of 108 parotid gland carcinoma patients who were treated at Kyushu University Hospital, Fukuoka, Japan, between 1983 and 2014 were reviewed. The survival outcomes were analysed according to clinicopathological findings.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001130_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Forty-six patients had low clinical stage tumours (I\u2013II), and 62 patients had high clinical stage tumours (III\u2013IV). Fifty-two, 10 and 46 patients had low-, intermediate- and high-grade tumours, respectively. Twenty-seven of 65 cases had positive surgical margins. In high clinical stage and intermediate- to high-grade tumours, adjuvant radiation therapy was correlated with local recurrence-free survival (<jats:italic>p<\/jats:italic> = 0.0244). Intermediate- to high-grade tumours and positive surgical margins were significantly associated with disease-specific survival in multivariate analysis (<jats:italic>p<\/jats:italic> = 0.0002 and <jats:italic>p<\/jats:italic> = 0.0058).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001130_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The results of this study show that adjuvant radiation therapy is useful for improved local control in patients with high clinical stage and intermediate- to high-grade tumours.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215119001130","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T06:30:58Z","timestamp":1559802658000},"page":"604-609","source":"Crossref","is-referenced-by-count":14,"title":["Parotid gland carcinoma: 32 years\u2019 experience from a single institute"],"prefix":"10.1017","volume":"133","author":[{"given":"T","family":"Nakano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Yasumatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Kogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Asai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ohga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"S0022215119001130_ref2","first-page":"209","volume-title":"Pathology and Genetics of Head and Neck Tumours. World Health Organization Classification of Tumours","author":"Eveson","year":"2005"},{"key":"S0022215119001130_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-012-0350-9"},{"key":"S0022215119001130_ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000355219"},{"key":"S0022215119001130_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.10.012"},{"key":"S0022215119001130_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-015-0097-z"},{"key":"S0022215119001130_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815594789"},{"key":"S0022215119001130_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.04.052"},{"key":"S0022215119001130_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21083"},{"key":"S0022215119001130_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200308000-00028"},{"key":"S0022215119001130_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.05.021"},{"key":"S0022215119001130_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.02.003"},{"key":"S0022215119001130_ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.3025"},{"key":"S0022215119001130_ref15","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.20986"},{"key":"S0022215119001130_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.07.010"},{"key":"S0022215119001130_ref19","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0369"},{"key":"S0022215119001130_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10400"},{"key":"S0022215119001130_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.10.009"},{"key":"S0022215119001130_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197712)40:6<2882::AID-CNCR2820400618>3.0.CO;2-I"},{"key":"S0022215119001130_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21870"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215119001130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T07:53:20Z","timestamp":1566201200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215119001130\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0022215119001130"],"URL":"https:\/\/doi.org\/10.1017\/s0022215119001130","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]}}}