{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:26:08Z","timestamp":1776335168893,"version":"3.51.2"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215119001440_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This study aims to investigate whether there is a correlation between serum calprotectin concentration and oral ulcer activity in patients with active recurrent aphthous stomatitis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001440_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This prospective, cross-sectional, historical cohort study included 52 patients (26 with active lesions and 26 with inactive lesions) with recurrent aphthous stomatitis and 27 healthy volunteers. The relationship between the groups was statistically evaluated in terms of serum calprotectin level and other inflammatory parameters.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001440_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The median calprotectin value of the active lesion group (80.5 ng\/ml) was significantly higher than that of the control group (55.4 ng\/ml,<jats:italic>p<\/jats:italic>= 0.002). Furthermore, the median calprotectin value of the active lesion group was significantly higher than that of the inactive lesion group (72.5 ng\/ml,<jats:italic>p<\/jats:italic>= 0.017).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119001440_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>In patients with recurrent aphthous stomatitis and active ulcer lesions, the serum calprotectin value can be used as a reliable and robust prognostic marker for inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215119001440","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T07:19:03Z","timestamp":1562656743000},"page":"691-695","source":"Crossref","is-referenced-by-count":4,"title":["A novel prognostic biomarker for recurrent aphthous stomatitis: calprotectin"],"prefix":"10.1017","volume":"133","author":[{"given":"S","family":"Kayabasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Kuzucu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"S0022215119001440_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-003-0073-z"},{"key":"S0022215119001440_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(00)80057-0"},{"key":"S0022215119001440_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(20000201)21:3<665::AID-ELPS665>3.0.CO;2-U"},{"key":"S0022215119001440_ref4","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1994.1112"},{"key":"S0022215119001440_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb00365.x"},{"key":"S0022215119001440_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01143.x"},{"key":"S0022215119001440_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-013-0261-y"},{"key":"S0022215119001440_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114001078"},{"key":"S0022215119001440_ref6","first-page":"6823","article-title":"Gastric cancers overexpress S100A calcium-binding proteins","volume":"62","author":"El-R\u0131fai","year":"2002","journal-title":"Cancer Res"},{"key":"S0022215119001440_ref7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.33549\/physiolres.930448","article-title":"Calprotectin\u2014a pleiotropic molecule in acute and chronic inflammation","volume":"53","author":"St\u0159\u00ed\u017e","year":"2004","journal-title":"Physiol Res"},{"key":"S0022215119001440_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1989.tb02185.x"},{"key":"S0022215119001440_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00803.x"},{"key":"S0022215119001440_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4480-4"},{"key":"S0022215119001440_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.01.022"},{"key":"S0022215119001440_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02780526"},{"key":"S0022215119001440_ref16","doi-asserted-by":"publisher","DOI":"10.4328\/JCAM.2619"},{"key":"S0022215119001440_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2015.10.010"},{"key":"S0022215119001440_ref17","doi-asserted-by":"publisher","DOI":"10.1177\/0003319713492375"},{"key":"S0022215119001440_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237485"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215119001440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T02:37:53Z","timestamp":1695004673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215119001440\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,9]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0022215119001440"],"URL":"https:\/\/doi.org\/10.1017\/s0022215119001440","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,9]]}}}