{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:38:45Z","timestamp":1770892725924,"version":"3.50.1"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215119002305_sec_a1\" sec-type=\"other\"><jats:title>Objective<\/jats:title><jats:p>To assess the effect of tranexamic acid in head and neck surgical procedures.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119002305_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A prospective, double-blind and randomised, parallel group, placebo-controlled clinical trial was conducted. Ninety-two patients undergoing various head and neck surgical procedures were randomised. Subjects received seven infusions of coded drugs (tranexamic acid or normal saline) starting at the time of skin closure. Haematological, biochemical, blood loss and other parameters were observed by the staff, who were blinded to patients\u2019 group allocation (case or control).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119002305_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Patients were analysed on the basis of type of surgery. Fifty patients who had undergone surgical procedures, including total thyroidectomy, total parotidectomy, and various neck dissections with or without primary tumour excision, were included in the first group. The second group comprised 41 patients who had undergone hemithyroidectomy, lobectomy or superficial parotidectomy. There was no statistical difference in blood parameters between both groups. There was a reduction in post-operative drain volume, but this was not significant.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119002305_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Although this prospective, randomised, placebo-controlled clinical trial found a reduction in post-operative drain volume in tranexamic acid groups, the difference was not statistically significant between the various head and neck surgical procedure groups.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215119002305","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T08:41:53Z","timestamp":1574066513000},"page":"1024-1032","source":"Crossref","is-referenced-by-count":7,"title":["Tranexamic acid has no advantage in head and neck surgical procedures: a randomised, double-blind, controlled clinical trial"],"prefix":"10.1017","volume":"133","author":[{"given":"A","family":"Thakur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Minhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R K","family":"Azad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Vasanthalakshmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N K","family":"Mohindroo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"S0022215119002305_ref7","first-page":"227","article-title":"Efficacy of tranexamic acid in decreasing blood loss during and after caesarean section: a randomized case controlled prospective study","volume":"57","author":"Gohel","year":"2007","journal-title":"J Obstet Gynecol"},{"key":"S0022215119002305_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200207000-00028"},{"key":"S0022215119002305_ref6","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199957060-00017"},{"key":"S0022215119002305_ref4","first-page":"274","article-title":"Does adrenaline spraying over thyroidectomy area reduce bleeding?","volume":"7","author":"Ersoy","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"S0022215119002305_ref9","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.174798"},{"key":"S0022215119002305_ref10","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.161806"},{"key":"S0022215119002305_ref1","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2003.35365"},{"key":"S0022215119002305_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009460"},{"key":"S0022215119002305_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-184"},{"key":"S0022215119002305_ref5","first-page":"3058754","article-title":"Haemostasis in thyroid surgery: collagen-fibrinogen-thrombin patch versus cellulose gauze--our experience","volume":"2016","author":"Tartaglia","year":"2016","journal-title":"Surg Res Pract"},{"key":"S0022215119002305_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4829"},{"key":"S0022215119002305_ref15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/1658-354X.93057","article-title":"Efficacy of tranexamic acid on blood loss during bimaxillary osteotomy: a randomized double blind clinical trial","volume":"6","author":"Karimi","year":"2012","journal-title":"Saudi J Anaesth"},{"key":"S0022215119002305_ref3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00268-003-7193-3","article-title":"Surgical site infections in breast surgery: case-control study","volume":"28","author":"Vilar-Compte","year":"2004","journal-title":"World J Surg"},{"key":"S0022215119002305_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.02.022"},{"key":"S0022215119002305_ref11","first-page":"T150","volume-title":"Therapeutic Drugs","author":"Dollery","year":"1998"},{"key":"S0022215119002305_ref16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/1658-354X.115314","article-title":"Effects of tranexamic acid during endoscopic sinus surgery in children","volume":"7","author":"Eldaba","year":"2013","journal-title":"Saudi J Anaesth"}],"container-title":["The Journal of Laryngology &amp; 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