{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:23:55Z","timestamp":1789712635952,"version":"4.0.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215119002391_sec_a1\" sec-type=\"other\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the impact of platelet-rich fibrin therapy in tympanoplasty type 1 surgery on graft survival and frequency-specific hearing outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119002391_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Patients who underwent tympanoplasty type 1 surgery were randomised into temporal fascia graft alone (<jats:italic>n<\/jats:italic>= 55) and temporal fascia graft plus platelet-rich fibrin therapy (<jats:italic>n<\/jats:italic>= 36) groups. Graft survival and hearing outcomes were recorded.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119002391_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Graft survival rates were significantly higher in the temporal fascia graft plus platelet-rich fibrin therapy group than in the temporal fascia graft alone group at one (100.0<jats:italic>vs<\/jats:italic>85.5 per cent,<jats:italic>p<\/jats:italic>= 0.020), three (97.2<jats:italic>vs<\/jats:italic>80.0 per cent,<jats:italic>p<\/jats:italic>= 0.024) and six months post-operatively (94.4<jats:italic>vs<\/jats:italic>74.5 per cent,<jats:italic>p<\/jats:italic>= 0.031). The difference in hearing gain between groups was not significant.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215119002391_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Our findings revealed that the use of a platelet-rich fibrin plus temporal fascia graft for type 1 tympanoplasty was associated with more favourable post-operative outcomes than the use of temporal fascia alone, both in terms of tympanic membrane healing and graft survival; hearing restoration outcomes were similar.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215119002391","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T08:41:53Z","timestamp":1574066513000},"page":"1068-1073","source":"Crossref","is-referenced-by-count":23,"title":["Impact of platelet-rich fibrin therapy in tympanoplasty type 1 surgery on graft survival and frequency-specific hearing outcomes: a retrospective analysis in patients with tympanic membrane perforation due to chronic otitis media"],"prefix":"10.1017","volume":"133","author":[{"given":"S","family":"G\u00f6k\u00e7e K\u00fct\u00fck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"\u00d6zda\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"S0022215119002391_ref23","first-page":"175","article-title":"The relevance of Choukroun's platelet-rich fibrin (PRF) during middle ear surgery: preliminary results [in French]","volume":"130","author":"Braccini","year":"2009","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"S0022215119002391_ref6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/MAO.0b013e3181dbb35e","article-title":"Efficacy of cartilage palisade tympanoplasty: randomized controlled trial","volume":"31","author":"Cabra","year":"2010","journal-title":"Otol Neurotol"},{"key":"S0022215119002391_ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-018-0289-4"},{"key":"S0022215119002391_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.04.013"},{"key":"S0022215119002391_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-017-1137-y"},{"key":"S0022215119002391_ref25","first-page":"63","article-title":"Comparison of tympanoplasty results with use of perichondrium-cartilage and temporalis facia","volume":"21","author":"Hashemi","year":"2009","journal-title":"Iran J Otorhinolaryngol"},{"key":"S0022215119002391_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100051240"},{"key":"S0022215119002391_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2008.11.009"},{"key":"S0022215119002391_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116008446"},{"key":"S0022215119002391_ref19","first-page":"181","article-title":"Effectiveness of topical phenytoin therapy versus platelet-rich plasma for tympanic perforations closure: comparative study","volume":"79","author":"Ayala-Montes de Oca","year":"2016","journal-title":"Rev Med Hosp Gen (Mex)"},{"key":"S0022215119002391_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200403000-00029"},{"key":"S0022215119002391_ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2431023"},{"key":"S0022215119002391_ref8","first-page":"Doc07","article-title":"Tympanoplasty - news and new perspectives","volume":"16","author":"Neudert","year":"2017","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg"},{"key":"S0022215119002391_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/2001-1326-3-5"},{"key":"S0022215119002391_ref11","first-page":"93","article-title":"Is platelet-rich plasma the perfect enhancement factor? 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