{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:05:19Z","timestamp":1787965519552,"version":"build-2784847793"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"unspecified","delay-in-days":2,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2019,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Early laryngeal cancer treated with definitive radiotherapy or surgery has a high cure rate. This study evaluated the patterns of treatment failure and long-term results of early laryngeal cancers treated with definitive radiotherapy.<\/jats:p><\/jats:sec>Method<\/jats:title>From January 2002 to December 2014, a total of 242 patients with early-stage laryngeal cancers were treated with radical radiotherapy.<\/jats:p><\/jats:sec>Results<\/jats:title>All patients had squamous cell carcinoma of the larynx (92 per cent male and 8 per cent female). Median follow-up was 4.5 years. The majority of patients were smokers (57.4 per cent). Local failure was seen in 12.5 per cent of stage I patients and 22.8 per cent of stage II patients. The 5-year overall survival and disease specific survival were 84 per cent and 91 per cent, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In summary, radiotherapy is a suitable treatment modality for patients with early-stage laryngeal cancer, with an overall locoregional control rate of 84 per cent. Patients who fail radiotherapy may still undergo salvage laryngectomy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215119002433","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T06:44:08Z","timestamp":1575355448000},"page":"1087-1091","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure"],"prefix":"10.1017","volume":"133","author":[{"given":"M","family":"Adeel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Faisal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Rasheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K I","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Y","family":"Hameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jamshed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"S0022215119002433_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20181"},{"key":"S0022215119002433_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-193"},{"key":"S0022215119002433_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.018"},{"key":"S0022215119002433_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.013"},{"key":"S0022215119002433_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11575"},{"key":"S0022215119002433_ref7","first-page":"900","article-title":"Larynx cancer","volume":"4","author":"Slavicek","year":"2002","journal-title":"Postgraduate medicine"},{"key":"S0022215119002433_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90220-9"},{"key":"S0022215119002433_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000236095.97947.26"},{"key":"S0022215119002433_ref2","volume-title":"Cancer Incidence, Prevalence and Mortality Worldwide","author":"Ferlay","year":"2001"},{"key":"S0022215119002433_ref1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"S0022215119002433_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00118-4"},{"key":"S0022215119002433_ref15","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711601107"},{"key":"S0022215119002433_ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.4559"},{"key":"S0022215119002433_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199812000-00016"},{"key":"S0022215119002433_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90490-M"},{"key":"S0022215119002433_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00226-0"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215119002433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T07:35:38Z","timestamp":1576827338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215119002433\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0022215119002433"],"URL":"https:\/\/doi.org\/10.1017\/s0022215119002433","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}