{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:35:05Z","timestamp":1787747705924,"version":"build-2784847793"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215120000158_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Topical nasal decongestants are frequently used as part of the medical management of symptoms related to Eustachian tube dysfunction.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000158_sec_a2\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess the effect of topical xylometazoline hydrochloride sprayed in the anterior part of the nose on Eustachian tube active and passive opening in healthy ears.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000158_sec_a3\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Active and passive Eustachian tube function was assessed in healthy subjects before and after intranasal administration of xylometazoline spray, using tympanometry, video otoscopy, sonotubometry, tubo-tympano-aerodynamic-graphy and tubomanometry.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000158_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Resting middle-ear pressures were not significantly different following decongestant application. Eustachian tube opening rate was not significantly different following the intervention, as measured by all function tests used. Sonotubometry data showed a significant increase in the duration of Eustachian tube opening following decongestant application.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000158_sec_a5\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>There remains little or no evidence that topical nasal decongestants improve Eustachian tube function. Sonotubometry findings do suggest that further investigation with an obstructive Eustachian tube dysfunction patient cohort is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215120000158","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T08:50:42Z","timestamp":1579683042000},"page":"29-33","source":"Crossref","is-referenced-by-count":10,"title":["The effect of topical xylometazoline on Eustachian tube function"],"prefix":"10.1017","volume":"134","author":[{"given":"K S","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V W Q","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Tysome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"S0022215120000158_ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0922-4106(95)90185-X","article-title":"Anti-oxidant actions of oxymethazoline and xylomethazoline","volume":"291","author":"Westerveld","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"S0022215120000158_ref3","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1177\/000348946807700610","article-title":"Effects of alpha and beta adrenergic agonists on nasal blood flow","volume":"77","author":"Hall","year":"1968","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"S0022215120000158_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26534"},{"key":"S0022215120000158_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-6757(98)90097-3"},{"key":"S0022215120000158_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206946"},{"key":"S0022215120000158_ref11","unstructured":"11 HealthCentral: Ear Discomfort and Airplane Travel. 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