{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:26:56Z","timestamp":1782973616692,"version":"3.54.5"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215120000602_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This paper presents a case of an isolated pituitary fossa metastasis on a background of a previously treated tonsillar squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000602_sec_a2\"><jats:title>Case report<\/jats:title><jats:p>A 64-year-old male, diagnosed with a primary p16-negative squamous cell carcinoma in the right tonsil, was treated with a course of chemoradiotherapy with curative intent. Positron emission tomography\/computed tomography, performed at six months post-treatment, revealed a good local response and no distant metastases. The patient was placed on routine follow up at two-monthly intervals. Two months into follow up, he presented with a right-sided oculomotor nerve palsy and partial Horner's syndrome. Imaging and biopsy revealed a pituitary fossa metastasis (p16-negative squamous cell carcinoma), and a further positron emission tomography\/computed tomography visualised this lesion. He was deemed unsuitable for further intervention and underwent palliative radiotherapy for symptom control.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000602_sec_a3\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>This case represents the first reported isolated pituitary fossa metastasis from a tonsillar squamous cell carcinoma. A high degree of clinical suspicion is recommended, along with a low threshold for biopsy and a cautioned use of positron emission tomography\/computed tomography, when investigating such patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215120000602","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T08:27:07Z","timestamp":1585729627000},"page":"369-371","source":"Crossref","is-referenced-by-count":4,"title":["Isolated pituitary fossa metastasis from a primary tonsillar squamous cell carcinoma: case report"],"prefix":"10.1017","volume":"134","author":[{"given":"H","family":"Merchant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Rye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"S0022215120000602_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72785-0"},{"key":"S0022215120000602_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-008-0145-0"},{"key":"S0022215120000602_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03881.x"},{"key":"S0022215120000602_ref15","first-page":"125","article-title":"Brain metastases detectability of routine whole body 18F-FDG PET and low dose CT scanning in 2502 asymptomatic patients with solid extracranial tumors","volume":"15","author":"Bochev","year":"2012","journal-title":"Hell J Nucl Med"},{"key":"S0022215120000602_ref6","first-page":"647256","article-title":"Sellar and parasellar metastatic tumors","volume":"2012","author":"Altay","year":"2012","journal-title":"Int J Surg Oncol"},{"key":"S0022215120000602_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.04.007"},{"key":"S0022215120000602_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-013-0542-9"},{"key":"S0022215120000602_ref16","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.6.1132"},{"key":"S0022215120000602_ref3","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.112478"},{"key":"S0022215120000602_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.06.139"},{"key":"S0022215120000602_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz003"},{"key":"S0022215120000602_ref4","doi-asserted-by":"publisher","DOI":"10.3171\/2018.2.FOCUS17761"},{"key":"S0022215120000602_ref19","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0448"},{"key":"S0022215120000602_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701687283"},{"key":"S0022215120000602_ref8","first-page":"983","article-title":"Prognostic factors in cancer patients with symptomatic pituitary metastasis: a clinical case study","volume":"35","author":"Lin","year":"2015","journal-title":"Anticancer Res"},{"key":"S0022215120000602_ref18","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11331"},{"key":"S0022215120000602_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20834"},{"key":"S0022215120000602_ref20","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/ijc.24842","article-title":"Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality","volume":"126","author":"Fischer","year":"2010","journal-title":"Int J Cancer"},{"key":"S0022215120000602_ref2","volume-title":"Otolaryngology: The Essentials","author":"Seiden","year":"2002"},{"key":"S0022215120000602_ref13","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v6.i5.177"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215120000602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T06:23:58Z","timestamp":1722666238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215120000602\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0022215120000602"],"URL":"https:\/\/doi.org\/10.1017\/s0022215120000602","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}