{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:24:19Z","timestamp":1768472659103,"version":"3.49.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215120000729_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Patients with non-Hodgkin's lymphoma and chronic lymphocytic leukaemia are at an elevated risk of further malignancy. Head and neck squamous cell carcinoma often presents with cervical lymph node metastasis, and can pose a diagnostic challenge in patients with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia who may have pre-existing palpable neck nodes.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000729_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A retrospective case review of a health board was conducted to identify patients with head and neck squamous cell carcinoma with a previous diagnosis of non-Hodgkin's lymphoma or chronic lymphocytic leukaemia.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000729_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Four patients with head and neck squamous cell carcinoma that developed after non-Hodgkin's lymphoma or chronic lymphocytic leukaemia were identified. Two patients had a background of non-Hodgkin's lymphoma treated with chemotherapy. The remaining two patients had a background of chronic lymphocytic leukaemia under active surveillance. Three out of the four patients died within 30 months of diagnosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120000729_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Head and neck squamous cell carcinoma following non-Hodgkin's lymphoma or chronic lymphocytic leukaemia is aggressive. A heightened clinical suspicion is essential to facilitate early diagnosis and treatment of head and neck squamous cell carcinoma in patients with dual pathology.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215120000729","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T09:16:19Z","timestamp":1587374179000},"page":"460-462","source":"Crossref","is-referenced-by-count":2,"title":["Head and neck squamous cell cancer associated with lymphoproliferative malignancies is aggressive"],"prefix":"10.1017","volume":"134","author":[{"given":"L","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"S0022215120000729_ref26","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816631726"},{"key":"S0022215120000729_ref27","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.642"},{"key":"S0022215120000729_ref7","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0033-8389(22)01257-X","article-title":"Lymphoma of the head and neck","volume":"28","author":"DePe\u00f1a","year":"1990","journal-title":"Radiol Clin North Am"},{"key":"S0022215120000729_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22672"},{"key":"S0022215120000729_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2006.07.002"},{"key":"S0022215120000729_ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.2200"},{"key":"S0022215120000729_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215105000782"},{"key":"S0022215120000729_ref1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1998"},{"key":"S0022215120000729_ref29","doi-asserted-by":"publisher","DOI":"10.4103\/cytojournal.cytojournal_20_17"},{"key":"S0022215120000729_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4+<1786::AID-CNCR2820400803>3.0.CO;2-2"},{"key":"S0022215120000729_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602654"},{"key":"S0022215120000729_ref21","volume-title":"TNM Classification of Malignant Tumours","author":"Sobin","year":"2009"},{"key":"S0022215120000729_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3958"},{"key":"S0022215120000729_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2010.04.003"},{"key":"S0022215120000729_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-015-0664-7"},{"key":"S0022215120000729_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20955"},{"key":"S0022215120000729_ref23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.2.312"},{"key":"S0022215120000729_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2008.10.012"},{"key":"S0022215120000729_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-010-0228-9"},{"key":"S0022215120000729_ref20","first-page":"465","article-title":"Adenosquamous carcinoma of the thyroid after radiotherapy for Hodgkin's disease","volume":"52","author":"Bakri","year":"1983","journal-title":"A case report and review. 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