{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:27:20Z","timestamp":1760956040203},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"unspecified","delay-in-days":35,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215120001073_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To predict skull base osteomyelitis in patients with necrotising otitis externa using diffusion-weighted imaging.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120001073_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted of 25 necrotising otitis externa patients with skull base osteomyelitis (<jats:italic>n<\/jats:italic> = 10) or without skull base involvement (<jats:italic>n<\/jats:italic> = 14) who underwent a single-shot diffusion-weighted imaging of the skull base.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120001073_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The respective mean apparent diffusion coefficient values of the skull base, as determined by two reviewers, were 0.851 \u00b1 0.15 and 0.841 \u00b1 0.14 \u00d710<jats:sup>-3<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s for the skull base osteomyelitis patients, and 1.065 \u00b1 0.19 and 1.045 \u00b1 0.20 \u00d710<jats:sup>-3<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s for the necrotising otitis externa patients without skull base involvement. The difference in apparent diffusion coefficients between the groups was significant, for both reviewers (<jats:italic>p<\/jats:italic> = 0.008 and 0.012). The optimal threshold apparent diffusion coefficient for predicting skull base osteomyelitis in necrotising otitis externa patients was 0.945 \u00d710<jats:sup>-3<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s and 0.915 \u00d710<jats:sup>-3<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s, with an area under the curve of 0.825 and 0.800, accuracy of 87.5 and 83.3 per cent, sensitivity of 85.7 and 90.0 per cent, and specificity of 90.0 and 78.6 per cent, for each reviewer respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120001073_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Apparent diffusion coefficient is a non-invasive imaging parameter useful for predicting skull base osteomyelitis in necrotising otitis externa 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