{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T11:28:57Z","timestamp":1772364537142,"version":"3.50.1"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215120002479_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Thyroid lobectomy is recommended with total laryngectomy for laryngeal cancer in the National Comprehensive Cancer Network (\u2018NCCN\u2019) guidelines. However, it is associated with a 32\u201389 per cent risk of hypothyroidism, with or without adjuvant radiotherapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002479_sec_a2\"><jats:title>Objective<\/jats:title><jats:p>The study aimed to determine whether preserving the whole thyroid, compared to a single lobe, does indeed significantly lower the incidence of hypothyroidism in the setting of total laryngectomy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002479_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>A retrospective study was conducted at Groote Schuur Hospital in Cape Town, South Africa.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002479_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Eighty-four patients met the inclusion criteria. The overall incidence of hypothyroidism was 45.2 per cent. The incidence of hypothyroidism was significantly reduced in patients who underwent thyroid-sparing total laryngectomy compared to hemithyroidectomy (<jats:italic>p<\/jats:italic> = 0.037). Adjuvant radiotherapy was associated with a higher incidence of hypothyroidism (<jats:italic>p<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002479_sec_a5\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Thyroid-preserving laryngectomy should be advocated in carefully selected patients with advanced laryngeal carcinoma, as it reduces the incidence of hypothyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215120002479","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T07:11:19Z","timestamp":1606461079000},"page":"1069-1072","source":"Crossref","is-referenced-by-count":3,"title":["Does thyroid-sparing total laryngectomy decrease the risk of hypothyroidism?"],"prefix":"10.1017","volume":"134","author":[{"given":"G","family":"Viljoen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J K","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Alhadad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Dalvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"S0022215120002479_ref31","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1210\/jc.2012-1063","article-title":"Risk of hypothyroidism following hemithyroidectomy: systematic review and meta-analysis of prognostic studies","volume":"97","author":"Verloop","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"S0022215120002479_ref36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1096-9098(199604)61:4<281::AID-JSO10>3.0.CO;2-9","article-title":"Postradiotherapy hypothyroidism: radiation dose response and chemotherapeutic radiosensitization at less than 40 Gy","volume":"61","author":"Kuten","year":"1996","journal-title":"J Surg Oncol"},{"key":"S0022215120002479_ref13","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/lary.28235","article-title":"Does thyroid gland preserving total laryngectomy affect oncological control in laryngeal carcinoma","volume":"130","author":"McGuire","year":"2020","journal-title":"Laryngoscope"},{"key":"S0022215120002479_ref24","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1007\/s00268-013-2201-8","article-title":"Hypothyroidism after hemithyroidectomy","volume":"37","author":"Said","year":"2013","journal-title":"World J Surg"},{"key":"S0022215120002479_ref29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1097-0347(199601\/02)18:1<54::AID-HED7>3.0.CO;2-Y","article-title":"Prevention of stomal recurrence","volume":"18","author":"Le\u00f3n","year":"1996","journal-title":"Head Neck"},{"key":"S0022215120002479_ref34","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijrobp.2006.08.051","article-title":"Thyroid disorders in patients treated with radiotherapy for head-and-neck cancer: a retrospective analysis of seventy-three patients","volume":"67","author":"Alterio","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"S0022215120002479_ref6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/hed.20693","article-title":"Thyroid dysfunction in laryngectomees\u201410 years after treatment","volume":"30","author":"Ho","year":"2008","journal-title":"Head Neck"},{"key":"S0022215120002479_ref26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1067\/mhn.2000.107528","article-title":"Risk factors associated with hypothyroidism after laryngectomy","volume":"123","author":"Gal","year":"2000","journal-title":"Otolaryngol Neck Surg"},{"key":"S0022215120002479_ref2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.anl.2013.10.004","article-title":"Clinical effectiveness of thyroidectomy on the management of locally advanced laryngeal cancer","volume":"41","author":"G\u00fcrb\u00fcz","year":"2014","journal-title":"Auris Nasus Larynx"},{"key":"S0022215120002479_ref5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00405-001-0418-x","article-title":"Hypothyroidism in patients treated with total laryngectomy. 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