{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:26:57Z","timestamp":1789586817035,"version":"build-2803163510"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215120002492_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Laryngopharyngeal reflux symptoms assessed with the reflux symptom index can overlap with non-allergic rhinitis symptoms. This study aims to explore the association between the reflux symptom index and nasal symptoms in non-allergic rhinitis patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002492_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A cross-sectional study was conducted on consecutive adults with non-allergic rhinitis. The reflux symptom index (score of more than 13 = laryngopharyngeal reflux) and nasal symptoms (categorised as mild (total score of 0\u20133), moderate (4\u20137) or severe (8\u201312)) were assessed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002492_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The study included 227 participants (aged 58.64 \u00b1 12.39 years, 59.5 per cent female). The reflux symptom index scores increased with total nasal symptom scores (mild <jats:italic>vs<\/jats:italic> moderate <jats:italic>vs<\/jats:italic> severe, 8.61 \u00b1 6.27 <jats:italic>vs<\/jats:italic> 12.94 \u00b1 7.4 <jats:italic>vs<\/jats:italic> 16.40 \u00b1 8.10; <jats:italic>p<\/jats:italic> &lt; 0.01). Logistic regression indicated that laryngopharyngeal reflux is more likely in patients with severe nose block (odds ratio 5.47 (95 per cent confidence interval = 2.16\u201313.87); <jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002492_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Laryngopharyngeal reflux symptoms are associated with nasal symptom severity, and nasal symptoms should be primarily treated. Those with predominant nose block and laryngopharyngeal reflux symptoms are more likely to have laryngopharyngeal reflux.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215120002492","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T05:55:50Z","timestamp":1611640550000},"page":"142-146","source":"Crossref","is-referenced-by-count":12,"title":["The association between the reflux symptoms index and nasal symptoms among patients with non-allergic rhinitis"],"prefix":"10.1017","volume":"135","author":[{"given":"A W","family":"Hamizan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Y","family":"Choo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P V","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N F","family":"Abd Talib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Mohd Ramli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F D","family":"Zahedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Husain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"S0022215120002492_ref21","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4286"},{"key":"S0022215120002492_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215111000120"},{"key":"S0022215120002492_ref13","doi-asserted-by":"publisher","DOI":"10.3109\/14015430903002262"},{"key":"S0022215120002492_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892419850750"},{"key":"S0022215120002492_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3181a8e389"},{"key":"S0022215120002492_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"S0022215120002492_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(16)30241-9"},{"key":"S0022215120002492_ref22","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2018.1436768"},{"key":"S0022215120002492_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12179"},{"key":"S0022215120002492_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.04.039"},{"key":"S0022215120002492_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2019.12.004"},{"key":"S0022215120002492_ref12","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000803"},{"key":"S0022215120002492_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2682-y"},{"key":"S0022215120002492_ref14","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2018.18.03.014"},{"key":"S0022215120002492_ref5","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.119.1388"},{"key":"S0022215120002492_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2017.02.002"},{"key":"S0022215120002492_ref15","first-page":"377","article-title":"Role of PH monitoring in laryngopharyngeal reflux patients with voice disorders","volume":"28","author":"Maldhure","year":"2016","journal-title":"Iran J Otorhinolaryngol"},{"key":"S0022215120002492_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.4127"},{"key":"S0022215120002492_ref6","first-page":"200","article-title":"Sensitisation to common allergens in children with allergic rhinitis","volume":"7","author":"Zahedi","year":"2011","journal-title":"Brunei Int Med J"},{"key":"S0022215120002492_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13005"},{"key":"S0022215120002492_ref7","first-page":"18","article-title":"Skin prick test reactivity to common aeroallergens among patients with rhinitis","volume":"1","author":"Samiah Yasmin","year":"2013","journal-title":"Am J Res Commun"},{"key":"S0022215120002492_ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2951928"}],"container-title":["The Journal of Laryngology &amp; 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