{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:17:49Z","timestamp":1773029869045,"version":"3.50.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"unspecified","delay-in-days":42,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215120002704_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Wide-ranging outcomes have been reported for surgical and non-surgical management of T<jats:sub>3<\/jats:sub> laryngeal carcinomas. This study compared the outcomes of T<jats:sub>3<\/jats:sub> tumours treated with laryngectomy or (chemo)radiotherapy in the northeast of England.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002704_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The outcomes of T<jats:sub>3<\/jats:sub> laryngeal carcinoma treatment at three centres (2007\u20132016) were retrospectively analysed using descriptive statistics and survival curves.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002704_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Of 179 T<jats:sub>3<\/jats:sub> laryngeal carcinomas, 68 were treated with laryngectomies, 57 with chemoradiotherapy and 32 with radiotherapy. There was no significant five-year survival difference between treatment with laryngectomy (34.1 per cent) and chemoradiotherapy (48.6 per cent) (<jats:italic>p<\/jats:italic> = 0.184). The five-year overall survival rate for radiotherapy (12.5 per cent) was significantly inferior compared to laryngectomy and chemoradiotherapy (<jats:italic>p<\/jats:italic> = 0.003 and <jats:italic>p<\/jats:italic> &lt; 0.001, respectively). The recurrence rates were 22.1 per cent for laryngectomy, 17.5 per cent for chemoradiotherapy and 50 per cent for radiotherapy. There were significant differences in recurrence rates when laryngectomy (<jats:italic>p<\/jats:italic> = 0.005) and chemoradiotherapy (<jats:italic>p<\/jats:italic> = 0.001) were compared to radiotherapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215120002704_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Laryngectomy and chemoradiotherapy had significantly higher five-year overall survival and lower recurrence rates compared with radiotherapy alone. Laryngectomy should be considered in patients unsuitable for chemotherapy, as it may convey a significant survival advantage over radiotherapy alone.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215120002704","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T01:47:41Z","timestamp":1610502461000},"page":"1103-1107","source":"Crossref","is-referenced-by-count":5,"title":["Treatment outcomes of laryngectomy compared to non-surgical management of T<sub>3<\/sub> laryngeal carcinomas: a 10-year multicentre audit of 179 patients in the northeast of England"],"prefix":"10.1017","volume":"134","author":[{"given":"D J","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Goodfellow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Y","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Lazarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H C","family":"Cocks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"S0022215120002704_ref5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/jamaoto.2016.1609","article-title":"Surgical vs nonsurgical treatment modalities for T3 glottic 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United Kingdom National Multidisciplinary guidelines","volume":"130","author":"Jones","year":"2016","journal-title":"J Laryngol Otol"},{"key":"S0022215120002704_ref4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1177\/0003489415588130","article-title":"Treatment selection for T3\/T4a laryngeal cancer: chemoradiation versus primary surgery","volume":"124","author":"Timme","year":"2015","journal-title":"Ann Otol Rhinol Laryngol"}],"container-title":["The Journal of Laryngology &amp; 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