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Otol."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121000323_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to provide a systematic review on survival outcome based on Pittsburgh T-staging for patients with primary external auditory canal squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121000323_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This study was a systematic review in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines performed until January 2018; pertinent studies were screened. Quality of evidence was assessed using the grading of recommendation, assessment, development and evaluation working group system.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121000323_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Eight articles were chosen that reported on 437 patients with external auditory carcinoma. The 5-year overall survival rate was 53.0 per cent. The pooled proportion of survivors at 5 years for T<jats:sub>1<\/jats:sub>tumours was 88.4 per cent and for T<jats:sub>2<\/jats:sub>tumours was 88.6 per cent. For the combined population of T<jats:sub>1<\/jats:sub>and T<jats:sub>2<\/jats:sub>cancer patients, it was 84.5 per cent. For T<jats:sub>3<\/jats:sub>and T<jats:sub>4<\/jats:sub>tumours, it was 53.3 per cent and 26.8 per cent, respectively, whereas for T<jats:sub>3<\/jats:sub>and T<jats:sub>4<\/jats:sub>tumours combined, it was 40.4 per cent. Individual analysis of 61 patients with presence of cervical nodes showed a poor survival rate.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121000323_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>From this review, there was not any significant difference found in the survival outcome between T<jats:sub>1<\/jats:sub>and T<jats:sub>2<\/jats:sub>tumours. A practical classification incorporating nodal status that accurately stratifies patients was proposed.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121000323","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T12:55:41Z","timestamp":1613048141000},"page":"96-103","source":"Crossref","is-referenced-by-count":12,"title":["A systematic review of the primary squamous cell carcinoma of the external auditory canal: survival outcome based on T-staging and proposal of a new classification"],"prefix":"10.1017","volume":"135","author":[{"given":"M","family":"George","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Borsotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Gereige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A 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