{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T13:41:08Z","timestamp":1651239668923},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121001304_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>British Thyroid Association 2014 guidelines emphasised ultrasound assessment of nodules. One ultrasonographic differentiator of debatable relevance is intra-nodular vascularity. This is the first UK study conducted to address this question.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121001304_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Ultrasound reports for thyroid surgery patients over 10 years were retrospectively reviewed. Reports documenting \u2018intra-nodular vascularity or flow\u2019 were analysed. Reports identifying peripheral vascularity only or no intra-nodular flow formed the control group. Concordance with final histology was used to determine the odds ratio for malignancy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121001304_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 306 patients were included, and 119 (38.9 per cent) nodules demonstrated intra-nodular vascularity. Of these, 60 (50.4 per cent) were malignant compared with 42 per cent in the control group. Intra-nodular vascularity was not a statistically significant predictor of malignancy with an odds ratio of 1.39 (<jats:italic>p =<\/jats:italic> 0.18, 95 per cent confidence interval, 0.86\u20132.23).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121001304_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Intra-nodular vascularity in isolation was not a reliable predictor of malignancy. This supports other world literature studies. Although intra-nodular flow should not be relied upon in isolation, interpretation in conjunction with other suspicious findings enhances the predictive value.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121001304","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T06:24:21Z","timestamp":1621578261000},"page":"599-601","source":"Crossref","is-referenced-by-count":0,"title":["Is sonographic intra-nodular vascularity a reliable predictor of thyroid malignancy? A UK tertiary centre study"],"prefix":"10.1017","volume":"135","author":[{"given":"E","family":"Omakobia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"McClean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"England","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Walden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"S0022215121001304_ref9","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2016.12.14"},{"key":"S0022215121001304_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.01.046"},{"key":"S0022215121001304_ref12","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1380041"},{"key":"S0022215121001304_ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000365416"},{"key":"S0022215121001304_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12692"},{"key":"S0022215121001304_ref4","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.198085"},{"key":"S0022215121001304_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000578"},{"key":"S0022215121001304_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12515"},{"key":"S0022215121001304_ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0766"},{"key":"S0022215121001304_ref1","unstructured":"1 Cancer Research UK. Thyroid cancer incidence statistics. In: https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/thyroid-cancer\/incidence. [20 November 2019]"},{"key":"S0022215121001304_ref8","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0353"},{"key":"S0022215121001304_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.18.2164"},{"key":"S0022215121001304_ref10","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2018.0103"},{"key":"S0022215121001304_ref7","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.03043"},{"key":"S0022215121001304_ref15","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000014"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215121001304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T12:59:29Z","timestamp":1651237169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215121001304\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,21]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0022215121001304"],"URL":"https:\/\/doi.org\/10.1017\/s0022215121001304","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,21]]}}}