{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:22:37Z","timestamp":1779916957739,"version":"3.53.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121001523_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This systematic review aimed to establish the evidence behind the use of pre-operative calcium, vitamin D or both calcium and vitamin D to prevent post-operative hypocalcaemia in patients undergoing thyroidectomy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121001523_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This review included prospective clinical trials on adult human patients that were published in English and which studied the effects of pre-operative supplementation with calcium, vitamin D or both calcium and vitamin D on the rate of post-operative hypocalcaemia following total thyroidectomy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121001523_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Seven out of the nine trials included reported statistically significantly reduced rates of post-operative laboratory hypocalcaemia (absolute risk reduction, 13\u201359 per cent) and symptomatic hypocalcaemia (absolute reduction, 11\u201340 per cent) following pre-operative supplementation.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121001523_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Pre-operative treatment with calcium, vitamin D or both calcium and vitamin D reduces the risk of post-operative hypocalcaemia and should be considered in patients undergoing total thyroidectomy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121001523","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T05:37:15Z","timestamp":1623649035000},"page":"568-573","source":"Crossref","is-referenced-by-count":20,"title":["Use of pre-operative calcium and vitamin D supplementation to prevent post-operative hypocalcaemia in patients undergoing thyroidectomy: a systematic 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