{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:29:40Z","timestamp":1776086980399,"version":"3.50.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121002103_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002103_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002103_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002103_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121002103","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T05:08:09Z","timestamp":1628140089000},"page":"879-882","source":"Crossref","is-referenced-by-count":4,"title":["Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction"],"prefix":"10.1017","volume":"135","author":[{"given":"A","family":"\u00d6zg\u00fcr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yemi\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ba\u015fbulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N F","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Akg\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Mehel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"\u00c7elebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"S0022215121002103_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0623-x"},{"key":"S0022215121002103_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3291-0"},{"key":"S0022215121002103_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00009"},{"key":"S0022215121002103_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00368-9"},{"key":"S0022215121002103_ref20","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2020.1717609"},{"key":"S0022215121002103_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4422-6"},{"key":"S0022215121002103_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000224345.59291.da"},{"key":"S0022215121002103_ref3","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2015.01662"},{"key":"S0022215121002103_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-019-00618-w"},{"key":"S0022215121002103_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-015-0655-5"},{"key":"S0022215121002103_ref14","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.2071"},{"key":"S0022215121002103_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05970-4"},{"key":"S0022215121002103_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-020-00253-6"},{"key":"S0022215121002103_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-019-00727-1"},{"key":"S0022215121002103_ref19","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700615"},{"key":"S0022215121002103_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02694481"},{"key":"S0022215121002103_ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00511"},{"key":"S0022215121002103_ref17","first-page":"1011","article-title":"Evaluation of tartrate-resistant acid phosphatase (TRAP) 5b as serum marker of bone metastases in human breast cancer","volume":"23","author":"Capeller","year":"2003","journal-title":"Anticancer Res"},{"key":"S0022215121002103_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-007-9091-4"},{"key":"S0022215121002103_ref18","first-page":"219","article-title":"Tartrate-resistant acid phosphatase (TRAP) as a serum marker for bone resorption in breast cancer patients with bone metastases","volume":"36","author":"Tauchert","year":"2009","journal-title":"Clin Exp Obstet Gynecol"},{"key":"S0022215121002103_ref8","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1222549"}],"container-title":["The Journal of Laryngology &amp; 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