{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:08:43Z","timestamp":1774494523076,"version":"3.50.1"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121002152_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Sinonasal inverted papillomas are challenging benign tumours of the nasal cavity because of their high recurrence rates and the lifetime malignant transformation risk of 10 per cent as well as their locally aggressive behaviour. This study aimed to describe treatment strategies for inverted papillomas with intracranial or intraorbital involvement.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002152_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This was a prospective case series study of 18 patients with inverted papilloma with intracranial or intraorbital involvement. Patient demographic data, imaging, pathology, surgical technique and recurrences were recorded prospectively over a period of seven years.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002152_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 83 per cent of the patients in this study had been previously operated on, consisting of 8 cases with intracranial involvement, 1 case with intraorbital involvement and 9 with both. During follow up with a medium of 37 months (range, 13\u2013115 months) there were two recurrences.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002152_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>It was postulated that intracranial or intraorbital involvement observed in this series was the result of multiple revisions. However, using accurate imaging protocols and the pedicle-oriented approach for tumour excision, complete tumour removal was achieved in most cases with minimal post-operative complications.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121002152","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T06:09:07Z","timestamp":1629871747000},"page":"904-910","source":"Crossref","is-referenced-by-count":5,"title":["Treatment strategies for inverted papillomas with intracranial or intraorbital involvement"],"prefix":"10.1017","volume":"135","author":[{"given":"D","family":"Spinos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kalamatianos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Terzakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Piagkou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Georgalas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"S0022215121002152_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1196-0"},{"key":"S0022215121002152_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200006000-00015"},{"key":"S0022215121002152_ref8","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3732"},{"key":"S0022215121002152_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22305"},{"key":"S0022215121002152_ref17","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001904284"},{"key":"S0022215121002152_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24481"},{"key":"S0022215121002152_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24929"},{"key":"S0022215121002152_ref18","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2984"},{"key":"S0022215121002152_ref3","first-page":"1","article-title":"European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base","volume":"22","author":"Lund","year":"2010","journal-title":"Rhinol Suppl"},{"key":"S0022215121002152_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.038"},{"key":"S0022215121002152_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3751-1"},{"key":"S0022215121002152_ref21","doi-asserted-by":"publisher","DOI":"10.2500\/105065899782102827"},{"key":"S0022215121002152_ref10","first-page":"15","article-title":"Endoscopic management of sinonasal inverted papilloma","volume":"66","author":"Bathma","year":"2011","journal-title":"Med J Malaysia"},{"key":"S0022215121002152_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25522"},{"key":"S0022215121002152_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816639019"},{"key":"S0022215121002152_ref22","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000230401.88711.e6"},{"key":"S0022215121002152_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117000172"},{"key":"S0022215121002152_ref9","doi-asserted-by":"crossref","unstructured":"9 Georgalas, C , Wytske, F . 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