{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T03:08:51Z","timestamp":1674961731963},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121002188_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Magnetic resonance imaging utilising non-echo planar diffusion-weighted imaging is known to have high sensitivity and specificity in detecting cholesteatoma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002188_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Data was retrospectively collected from patients who had undergone non-echo planar diffusion-weighted imaging from 1 January 2010 to 31 December 2016. The ratio of average pixel grey-scale values between the middle-ear lesion, pons and temporal lobe was used to quantify the degree of restricted diffusion and assess the statistical significance to detect cholesteatoma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002188_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 107 patients had non-echo planar diffusion-weighted imaging during the study period. Non-echo planar diffusion-weighted imaging shows good specificity and sensitivity with an excellent positive predictive value and accuracy. Analysis of the grey-scale pixel ratio for cholesteatoma detection showed statistically significant results.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002188_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Non-echo planar diffusion-weighted magnetic resonance imaging is accurate for cholesteatoma assessment. When the middle-ear lesion non-echo planar diffusion-weighted imaging intensity is higher than the ipsilateral temporal lobe, it is highly suggestive of a cholesteatoma formation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121002188","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T09:48:55Z","timestamp":1629280135000},"page":"208-214","source":"Crossref","is-referenced-by-count":1,"title":["Magnetic resonance non-echo planar diffusion-weighted imaging accuracy in detecting cholesteatoma in comparison with clinical and surgical findings"],"prefix":"10.1017","volume":"136","author":[{"given":"N","family":"Al Zuhir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Zammit-Maempel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"S0022215121002188_ref7","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091140"},{"key":"S0022215121002188_ref9","first-page":"1331","article-title":"Diffusion-weighted MR imaging in acute ischemia: value of apparent diffusion coefficient and signal intensity thresholds in predicting tissue at risk and final infarct size","volume":"25","author":"Na","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"S0022215121002188_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418800833"},{"key":"S0022215121002188_ref10","first-page":"1833","article-title":"Diagnostic value of magnetic resonance imaging for middle ear cholesteatoma: a meta-analysis [in Chinese]","volume":"31","author":"She","year":"2017","journal-title":"Lin Chuang Erh Pi Yen Hou Ko Tsa Chih"},{"key":"S0022215121002188_ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7945482"},{"key":"S0022215121002188_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25941"},{"key":"S0022215121002188_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5082-5"},{"key":"S0022215121002188_ref2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2129"},{"key":"S0022215121002188_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3148"},{"key":"S0022215121002188_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12762"},{"key":"S0022215121002188_ref8","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130065"},{"key":"S0022215121002188_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001558"},{"key":"S0022215121002188_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5074-5"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215121002188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T14:17:29Z","timestamp":1647267449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215121002188\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0022215121002188"],"URL":"https:\/\/doi.org\/10.1017\/s0022215121002188","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]}}}