{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:30:06Z","timestamp":1777570206408,"version":"3.51.4"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121002280_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to compare the effectiveness of pharmacological therapy with and without direct maxillary sinus saline irrigation for the management of chronic rhinosinusitis without polyps.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002280_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>In this prospective randomised controlled trial, 39 non-operated patients were randomly assigned to be treated with direct maxillary sinus saline irrigation in conjunction with systemic antibiotics and topical sprays (<jats:italic>n =<\/jats:italic>24) or with pharmacological therapy alone (<jats:italic>n =<\/jats:italic>15). Endoscopy, Sino-Nasal Outcome Test and Lund\u2013MacKay computed tomography scores were obtained before, six weeks after and one to two years after treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002280_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Post-treatment Lund\u2013Mackay computed tomography scores were significantly improved in both cohorts, with no inter-cohort difference identified. Post-treatment nasal endoscopy scores were significantly improved in the study group but were similar to those measured in the control group. The Sino-Nasal Outcome Test-20 results showed improvement in both cohorts, with no difference between treatment arms.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002280_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Maxillary sinus puncture and irrigation with saline, combined with pharmacological treatment improves endoscopic findings in patients with chronic rhinosinusitis without polyps, but has no beneficial effect on symptoms and imaging findings over conservative treatment alone.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121002280","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T07:23:55Z","timestamp":1630481035000},"page":"229-236","source":"Crossref","is-referenced-by-count":4,"title":["Direct maxillary irrigation therapy in non-operated chronic sinusitis: a prospective randomised controlled trial"],"prefix":"10.1017","volume":"136","author":[{"given":"O","family":"Ronen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Marshak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Uri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Haberfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Cohen-Kerem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"S0022215121002280_ref7","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3221"},{"key":"S0022215121002280_ref1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"S0022215121002280_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13042"},{"key":"S0022215121002280_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.04.019"},{"key":"S0022215121002280_ref10","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.115909"},{"key":"S0022215121002280_ref9","first-page":"223","article-title":"Acute maxillary sinusitis--a comparison between 27 different treatment modes","volume":"20","author":"von Sydow","year":"1982","journal-title":"Rhinology"},{"key":"S0022215121002280_ref6","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/lary.24066","article-title":"Use of topical nasal therapies in the management of chronic rhinosinusitis","volume":"123","author":"Wei","year":"2013","journal-title":"Laryngoscope"},{"key":"S0022215121002280_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00027"},{"key":"S0022215121002280_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0339-y"},{"key":"S0022215121002280_ref8","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"key":"S0022215121002280_ref5","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino16.211"},{"key":"S0022215121002280_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"S0022215121002280_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21003"},{"key":"S0022215121002280_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.11.1115"},{"key":"S0022215121002280_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900116"},{"key":"S0022215121002280_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.09.015"},{"key":"S0022215121002280_ref19","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2004.02146"},{"key":"S0022215121002280_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.06.710"},{"key":"S0022215121002280_ref17","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3487"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215121002280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T11:17:10Z","timestamp":1673176630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215121002280\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0022215121002280"],"URL":"https:\/\/doi.org\/10.1017\/s0022215121002280","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,1]]}}}