{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:57:35Z","timestamp":1787162255319,"version":"build-2736575974"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215121002516_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intranasal corticosteroids are widely used for management of many upper airway diseases because of their ability to effectively deliver local relief of inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215121002516_sec_a2\">\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>This paper presents the case of a 51-year-old man with human immunodeficiency virus treated with ritonavir who was started on fluticasone intranasal spray for presumed chronic rhinosinusitis. Months after starting this therapy, he developed symptoms of Cushing's syndrome and avascular necrosis of the shoulder due to the pharmacological interactions between fluticasone and ritonavir.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215121002516_sec_a3\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although intranasal corticosteroids are deemed a low-risk route of drug administration, clinicians need to be vigilant in appropriately prescribing corticosteroids in the setting of drug potentiators, particularly in these high-risk patients. Alternative corticosteroids such as beclomethasone dipropionate should be considered in such cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215121002516","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:48:21Z","timestamp":1632790101000},"page":"1119-1122","source":"Crossref","is-referenced-by-count":3,"title":["Complications of combination intranasal corticosteroids and anti-retroviral therapy"],"prefix":"10.1017","volume":"135","author":[{"given":"J","family":"James","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Caulley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"S0022215121002516_ref27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2799"},{"key":"S0022215121002516_ref22","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001206010449"},{"key":"S0022215121002516_ref35","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306300"},{"key":"S0022215121002516_ref2","first-page":"CD011996","article-title":"Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis","author":"Chong","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"S0022215121002516_ref25","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0990"},{"key":"S0022215121002516_ref17","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.6.704"},{"key":"S0022215121002516_ref3","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.16.1458.33692"},{"key":"S0022215121002516_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92870-4"},{"key":"S0022215121002516_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr212"},{"key":"S0022215121002516_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12039"},{"key":"S0022215121002516_ref21","doi-asserted-by":"publisher","DOI":"10.1177\/096120339200100610"},{"key":"S0022215121002516_ref14","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115561"},{"key":"S0022215121002516_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-011-9580-0"},{"key":"S0022215121002516_ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201107-1174CI"},{"key":"S0022215121002516_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/2325957414567681"},{"key":"S0022215121002516_ref34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2001.01325.x"},{"key":"S0022215121002516_ref11","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.3848"},{"key":"S0022215121002516_ref29","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1056\/NEJM199205283262206","article-title":"Nontraumatic necrosis of bone (osteonecrosis)","volume":"326","author":"Mankin","year":"1992","journal-title":"N Engl J Med"},{"key":"S0022215121002516_ref30","first-page":"275","article-title":"Ritonavir","volume":"35","author":"Hsu","year":"1998","journal-title":"Clinical pharmacokinetics and interactions with other anti-HIV agents. 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