{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:52:34Z","timestamp":1747173154904,"version":"3.40.5"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121002681_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Vestibular schwannomas can demonstrate great heterogeneity in their behaviour; approximately one-third will grow and two-thirds will not. This study aimed to determine whether there are factors present at diagnosis that can help predict outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002681_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study compared data from 735 patients from the past 20 years. Analysis of serial magnetic resonance imaging was carried out to place patients into growing and non-growing cohorts. Factors including size, age, follow-up time and presence of balance symptoms were compared.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002681_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The median size of a growing vestibular schwannoma at diagnosis was 13 mm, whereas the non-growing median size was 10.65 mm (<jats:italic>p<\/jats:italic> &lt; 0.001). Balance symptoms were present in 60.76 per cent of growing vestibular schwannoma patients but only in 38.75 per cent of patients with non-growing vestibular schwannomas (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002681_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>This study highlights initial tumour size and balance symptoms as potential predictors of whether or not a vestibular schwannoma will grow; these results better facilitate our understanding of vestibular schwannoma natural history.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121002681","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T06:37:54Z","timestamp":1633070274000},"page":"934-938","source":"Crossref","is-referenced-by-count":2,"title":["Growing versus non-growing vestibular schwannomas: assessment of natural history"],"prefix":"10.1017","volume":"136","author":[{"given":"A","family":"Dardis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Donghun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-1661","authenticated-orcid":false,"given":"G","family":"Kontorinis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"S0022215121002681_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818770413"},{"key":"S0022215121002681_ref15","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.94.6.0922"},{"key":"S0022215121002681_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.01.019"},{"key":"S0022215121002681_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz153"},{"key":"S0022215121002681_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002448"},{"key":"S0022215121002681_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001169"},{"key":"S0022215121002681_ref14","first-page":"495","article-title":"Acoustic tumor growth: implications for treatment choices","volume":"20","author":"Fucci","year":"1999","journal-title":"Am J Otol"},{"key":"S0022215121002681_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25159"},{"key":"S0022215121002681_ref23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0039-1678708","article-title":"Clinical predictors leading to change of initial conservative treatment of 836 vestibular schwannomas","volume":"81","author":"Kleijwegt","year":"2020","journal-title":"J Neurol Surg B Skull Base"},{"key":"S0022215121002681_ref16","doi-asserted-by":"publisher","DOI":"10.3171\/2019.5.JNS1923"},{"key":"S0022215121002681_ref8","article-title":"The inflammatory microenvironment in vestibular schwannoma","volume":"2","author":"Hannan","year":"2020","journal-title":"Neurooncol Adv"},{"key":"S0022215121002681_ref26","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200109000-00021"},{"key":"S0022215121002681_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx510"},{"key":"S0022215121002681_ref20","doi-asserted-by":"publisher","DOI":"10.3171\/2009.4.JNS08895"},{"key":"S0022215121002681_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-015-1827-9"},{"key":"S0022215121002681_ref19","doi-asserted-by":"publisher","DOI":"10.3171\/2011.12.JNS111662"},{"key":"S0022215121002681_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.02.087"},{"key":"S0022215121002681_ref5","first-page":"5","article-title":"Stereotactic radiosurgery for vestibular schwannoma: International Stereotactic Radiosurgery Society (ISRS) practice guideline","volume":"5","author":"Tsao","year":"2017","journal-title":"J Radiosurg SBRT"},{"key":"S0022215121002681_ref27","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001219"},{"key":"S0022215121002681_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819835495"},{"key":"S0022215121002681_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.01.101"},{"key":"S0022215121002681_ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217752"},{"key":"S0022215121002681_ref18","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1635268"},{"key":"S0022215121002681_ref4","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S218670"},{"key":"S0022215121002681_ref25","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112001206"},{"key":"S0022215121002681_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2016.05.003"},{"key":"S0022215121002681_ref17","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2020.1717608"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215121002681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T09:44:59Z","timestamp":1664271899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215121002681\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0022215121002681"],"URL":"https:\/\/doi.org\/10.1017\/s0022215121002681","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"type":"print","value":"0022-2151"},{"type":"electronic","value":"1748-5460"}],"subject":[],"published":{"date-parts":[[2021,10,1]]}}}