{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:44:14Z","timestamp":1763988254246,"version":"3.40.5"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121002851_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Sudden hearing loss, or progressive hearing loss occurring over months to years, are well-established presentations. However, little is described in the medical literature on how to approach patients presenting with a rapidly progressive hearing loss occurring over weeks. This study aimed to evaluate the clinical significance of patients presenting with rapidly progressive hearing loss.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002851_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A case of rapidly progressive hearing loss occurring over 12 weeks is presented. A PubMed literature review was performed to determine the evidence-based differential diagnoses for rapidly progressive hearing loss.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002851_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Fifteen causes were identified for rapidly progressive hearing loss: intracranial aetiologies (meningioma, lymphoma, metastatic deposit, cavernous angioma, meningitis, superficial siderosis); paraneoplastic syndrome (small cell lung carcinoma, thymoma); inflammatory or autoimmune disorders (autoimmune inner-ear disease, sarcoidosis, vasculitis, Sj\u00f6gren's syndrome); infective disorders (syphilis, human immunodeficiency virus); and medication-induced causes.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002851_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Rapidly progressive hearing loss should be considered a \u2018red flag\u2019 symptom that warrants urgent action. Most causes are systemic or sinister in nature, and the patient's hearing loss can potentially be reversed.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121002851","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T06:34:35Z","timestamp":1634106875000},"page":"775-782","source":"Crossref","is-referenced-by-count":2,"title":["Rapidly progressive hearing loss occurring over weeks: review of differential diagnoses"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6552-337X","authenticated-orcid":false,"given":"C W","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Walters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Steele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Stafford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"S0022215121002851_ref30","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198106000-00002"},{"key":"S0022215121002851_ref29","first-page":"e1846","article-title":"Signs and symptoms of acoustic neuroma at initial presentation: an exploratory analysis","volume":"9","author":"Foley","year":"2017","journal-title":"Cureus"},{"key":"S0022215121002851_ref15","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500499599"},{"key":"S0022215121002851_ref38","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp042"},{"key":"S0022215121002851_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000300"},{"key":"S0022215121002851_ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-021-00506-0"},{"key":"S0022215121002851_ref1","unstructured":"1 Management of suspected unilateral idiopathic sudden sensorineural hearing loss in adults. 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