{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:04:22Z","timestamp":1784621062683,"version":"3.55.0"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Spontaneous regression is defined as the partial or complete disappearance of a malignant tumour proven by microscopic examination in the absence of any substantial treatment. This paper presents the case of an older woman whose advanced-stage tonsillar squamous cell carcinoma was noted to have spontaneously regressed at seven months.<\/jats:p>\n <\/jats:sec>\n \n Case report<\/jats:title>\n \n A 66-year-old woman presented with a 4-month history of dysphagia and odynophagia in September 2020. An exophytic tumour was seen on the right tonsil; this was diagnosed radiologically and histologically as a squamous cell carcinoma of the tonsils, with tumour\u2013node\u2013metastasis staging of T\n 4a<\/jats:sub>\n N\n 0<\/jats:sub>\n M\n 0<\/jats:sub>\n . The patient received best supportive care. Seven months later, the oropharyngeal lesion had disappeared, with no treatment. Subsequent computed tomography imaging showed radiological resolution of the previously noted right-sided oropharyngeal lesion.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Several mechanisms of spontaneous regression are discussed. Further studies should review this case in conjunction with other reports of spontaneous tumour regressions, to elucidate underlying mechanisms.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/s0022215121002899","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T01:49:29Z","timestamp":1634089769000},"page":"882-884","source":"Crossref","is-referenced-by-count":6,"title":["Spontaneous regression of advanced-stage oropharyngeal squamous cell carcinoma"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4242-0391","authenticated-orcid":false,"given":"K L","family":"Lau","sequence":"first","affiliation":[{"name":"Sunderland Royal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6552-337X","authenticated-orcid":false,"given":"C W","family":"Lee","sequence":"additional","affiliation":[{"name":"Sunderland Royal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Tustin","sequence":"additional","affiliation":[{"name":"Sunderland Royal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Stafford","sequence":"additional","affiliation":[{"name":"Sunderland Royal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"S0022215121002899_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(94)90410-3"},{"key":"S0022215121002899_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00034-2"},{"key":"S0022215121002899_ref12","first-page":"91","article-title":"A clinical, histopathological and immunohistochemical approach to the bewildering diagnosis of keratoacanthoma","volume":"15","author":"Zargaran","year":"2014","journal-title":"J Dent (Shiraz)"},{"key":"S0022215121002899_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.04.026"},{"key":"S0022215121002899_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181cd3158"},{"key":"S0022215121002899_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s002620100216"},{"key":"S0022215121002899_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-004-0404-6"},{"key":"S0022215121002899_ref2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.82887"},{"key":"S0022215121002899_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2015.08.040"},{"key":"S0022215121002899_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980300087-1"},{"key":"S0022215121002899_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90253-Z"},{"key":"S0022215121002899_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000614"},{"key":"S0022215121002899_ref6","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.33954"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215121002899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:42:43Z","timestamp":1784619763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215121002899\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0022215121002899"],"URL":"https:\/\/doi.org\/10.1017\/s0022215121002899","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]}}}