{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:02:58Z","timestamp":1782972178855,"version":"3.54.5"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121002942_sec_a1\"><jats:title>Objectives<\/jats:title><jats:p>Electrochemotherapy uses electric fields to facilitate the influx of chemotherapy into cancer cells, producing a targeted effect. For head and neck cancer, it is mainly used for palliation of non-skin-origin metastases. It is used infrequently in the UK. This paper presents our experience and a UK survey to identify its frequency of use.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002942_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Between 2016 and 2019, a prospective database was created and reviewed. Only patients with non-skin-origin metastatic head and neck cancer, with no other palliative options, were included. Survival length, complications and symptomatic benefit were assessed. The survey was conducted via e-mail.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002942_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Five patients were included: three with squamous cell carcinoma, one with esthesioneuroblastoma and one with hepatocellular carcinoma. Survival ranged from 1 month to over 20 months. Minor complications were seen. Only 15 out of 69 UK head and neck multidisciplinary teams offer electrochemotherapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121002942_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Electrochemotherapy is a well-tolerated adjunct to standard palliation of metastatic head and neck cancer, and is offered by a limited number of UK multidisciplinary teams.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121002942","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T08:40:43Z","timestamp":1635151243000},"page":"256-260","source":"Crossref","is-referenced-by-count":2,"title":["Electrochemotherapy for the palliative management of non-skin-origin head and neck cancer: case series and UK national survey"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-0740","authenticated-orcid":false,"given":"C","family":"McCaffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Y W","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C S","family":"Murugan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Muir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"S0022215121002942_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1454602"},{"key":"S0022215121002942_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcsup.2006.08.003"},{"key":"S0022215121002942_ref2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0289"},{"key":"S0022215121002942_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.06.399"},{"key":"S0022215121002942_ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"S0022215121002942_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.10.008"},{"key":"S0022215121002942_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2016.1207803"},{"key":"S0022215121002942_ref16","article-title":"Head and neck cancer: United Kingdom national multidisciplinary guidelines","volume":"130","author":"Paleri","year":"2016","journal-title":"J Laryngol Otol"},{"key":"S0022215121002942_ref11","unstructured":"11 National Institute for Health and Clinical Excellence. Electrochemotherapy for metastases in the skin from tumours of non-skin origin and melanoma: Interventional procedures guidance [IPG446]. In: https:\/\/www.nice.org.uk\/guidance\/IPG446 [11 July 2019]"},{"key":"S0022215121002942_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4490-2"},{"key":"S0022215121002942_ref3","first-page":"3415","article-title":"Electrochemotherapy in head and neck cancer: a review of an emerging cancer treatment","volume":"16","author":"De Virgilio","year":"2018","journal-title":"Oncol Lett"},{"key":"S0022215121002942_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90064-K"},{"key":"S0022215121002942_ref12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/hed.25454","article-title":"The DAHANCA 32 study: electrochemotherapy for recurrent mucosal head and neck cancer","volume":"41","author":"Plaschke","year":"2019","journal-title":"Head Neck"},{"key":"S0022215121002942_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcsup.2006.08.002"},{"key":"S0022215121002942_ref8","first-page":"133","article-title":"Electrochemotherapy: advantages and drawbacks in treatment of cancer patients","volume":"1","author":"Sersa","year":"2003","journal-title":"Cancer Ther"},{"key":"S0022215121002942_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(03)00073-2"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215121002942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T17:47:24Z","timestamp":1699724844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215121002942\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0022215121002942"],"URL":"https:\/\/doi.org\/10.1017\/s0022215121002942","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,25]]}}}