{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:18:45Z","timestamp":1792840725022,"version":"4.5.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215121003364_sec_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to summarise the evidence for efficacy of combination treatment of intranasal corticosteroid spray with oxymetazoline hydrochloride nasal spray for chronic rhinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215121003364_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Nine databases were systematically searched from study inception in September 2016 to 1 June 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215121003364_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 130 studies were screened, and 4 randomised controlled trials comprising 838 patients met inclusion criteria. The study found superior improvement of nasal congestion from onset of treatment to completion in intranasal corticosteroid spray and oxymetazoline hydrochloride groups compared with control groups. Intranasal corticosteroid spray and oxymetazoline hydrochloride use resulted in higher nasal volume (standard error of mean 1, 15.8 + 1.1 ml;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .03) compared with either placebo (12.1 + 0.9 ml) or oxymetazoline hydrochloride (12.4 + 0.8 ml) alone (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215121003364_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intranasal corticosteroid spray and oxymetazoline hydrochloride combination treatment may be superior in reducing rhinitis symptoms compared with either intranasal corticosteroid spray or oxymetazoline hydrochloride alone, without inducing rhinitis medicamentosa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215121003364","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T04:02:42Z","timestamp":1635307362000},"page":"8-16","source":"Crossref","is-referenced-by-count":11,"title":["Intranasal corticosteroid and oxymetazoline for chronic rhinitis: a systematic review"],"prefix":"10.1017","volume":"136","author":[{"given":"C L","family":"Neighbors","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Fernandez","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"S0022215121003364_ref28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00695.x"},{"key":"S0022215121003364_ref17","doi-asserted-by":"publisher","DOI":"10.1177\/1753465811403348"},{"key":"S0022215121003364_ref11","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.117717"},{"key":"S0022215121003364_ref21","first-page":"167","article-title":"Oxymetazoline nasal spray three times daily for four weeks in normal subjects is not associated with rebound congestion or tachyphylaxis","volume":"41","author":"Watanabe","year":"2003","journal-title":"Rhinology"},{"key":"S0022215121003364_ref12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200911-1701OC"},{"key":"S0022215121003364_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.037"},{"key":"S0022215121003364_ref7","first-page":"65","article-title":"Oxymetazoline hydrochloride combined with mometasone nasal spray for persistent nasal congestion (pilot study)","volume":"3","author":"Rael","year":"2011","journal-title":"WAO Journal"},{"key":"S0022215121003364_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.01.010"},{"key":"S0022215121003364_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.10.1128"},{"key":"S0022215121003364_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00744.x"},{"key":"S0022215121003364_ref6","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3864"},{"key":"S0022215121003364_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60408-5"},{"key":"S0022215121003364_ref24","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819841883"},{"key":"S0022215121003364_ref18","unstructured":"18 Invanz. (2012). In: PDR3D Digital Drug Database Retrieved. In: http:\/\/www.pdr3d.com\/ [17 October 2021]"},{"key":"S0022215121003364_ref16","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00076.x"},{"key":"S0022215121003364_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818807891"},{"key":"S0022215121003364_ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00972.x"},{"key":"S0022215121003364_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27566"},{"key":"S0022215121003364_ref13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"S0022215121003364_ref5","first-page":"30","article-title":"The effectiveness of oxymetazoline plus intranasal steroid in the treatment of chronic rhinitis: a randomised controlled trial","volume":"34","author":"Thongngarm","year":"2016","journal-title":"Asian Pac J allergy Immunol"},{"key":"S0022215121003364_ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199701000-00010"},{"key":"S0022215121003364_ref27","doi-asserted-by":"publisher","DOI":"10.2147\/IPRP.S129544"},{"key":"S0022215121003364_ref9","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.5.6.783"},{"key":"S0022215121003364_ref19","doi-asserted-by":"publisher","DOI":"10.1038\/srep40425"},{"key":"S0022215121003364_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80069-7"},{"key":"S0022215121003364_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.003"},{"key":"S0022215121003364_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.06.018"},{"key":"S0022215121003364_ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0941-z"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215121003364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T09:50:06Z","timestamp":1643968206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215121003364\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,27]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0022215121003364"],"URL":"https:\/\/doi.org\/10.1017\/s0022215121003364","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,27]]}}}