{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:24:11Z","timestamp":1773059051270,"version":"3.50.1"},"reference-count":52,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215121003625_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nasal septal perforations are defects of the septum. Symptomatic patients failing conservative measures may be considered for surgery; however, the surgery is challenging. This study describes a technique involving mucosal advancement flaps and autologous or acellular porcine interposition grafts and assessed the long-term closure rate and symptom control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215121003625_sec_a2\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This study looked at patients with symptomatic septal perforations who underwent surgery between 2005 and 2017. Symptoms were assessed pre- and post-operatively using a visual analogue scale. A literature search was performed for septal perforation repair techniques and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215121003625_sec_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 95 per cent of patients had complete closure of their septal perforations, 90 per cent had complete symptom control. There were statistically significant differences between the pre- and post-operative mean visual analogue scale score for epistaxis (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), crusting (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), whistling (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and nasal obstruction (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215121003625_sec_a4\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgical closure of nasal septal perforations with mucosal advancement flaps and an interposition graft is a reliable technique with excellent long-term outcomes.<\/jats:p>\n                  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