{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:18:14Z","timestamp":1785770294207,"version":"3.56.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121004205_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To determine histopathological changes in nasal mucosa associated with duration of nasal packing with Merocel tampons.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121004205_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This study included 24 healthy rabbits, 6 rabbits per group. In group A, no tampon was applied. In group B, Merocel nasal tampons were applied and removed after 24 hours. In group C, the tampons were removed after 48 hours. In group D, the tampons were removed after 5 days. Specimens were obtained from the septum of each rabbit, including cartilage. Histopathological examination was performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121004205_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Significant differences were observed in terms of inflammatory infiltration and loss of cilia between groups A and B. Significant differences were also observed in terms of inflammatory infiltration, haematoma, cilia loss, epithelium dysplasia and cartilage degeneration between groups B and C. There were significant differences in terms of cilia loss, epithelium dysplasia and subepithelial fibrosis between groups C and D. Cartilage degeneration was mild in one animal in group B and in two animals in group C, and was moderate in four animals in group C.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121004205_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>It is recommended that Merocel nasal tampons are removed within 48 hours to preserve nasal mucosal function. Keeping the pack longer may cause cartilage degeneration and other complications.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121004205","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T01:40:51Z","timestamp":1639964451000},"page":"750-754","source":"Crossref","is-referenced-by-count":5,"title":["Histopathological changes of nasal mucosa after nasal packing with Merocel"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-0886","authenticated-orcid":false,"given":"M","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bay\u0131nd\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"\u00c7i\u00e7ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0707-9984","authenticated-orcid":false,"given":"M","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"S0022215121004205_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.12.009"},{"key":"S0022215121004205_ref2","first-page":"49","article-title":"Packing and stents in endonasal surgery","volume":"38","author":"Weber","year":"2000","journal-title":"Rhinology"},{"key":"S0022215121004205_ref12","first-page":"68","article-title":"Optimal time for nasal packing removal after septoplasty. 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