{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:34:40Z","timestamp":1777620880673,"version":"3.51.4"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215121004679_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the clinical significance of granulation tissue after endoscopic carbon dioxide laser surgery for glottic cancer.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121004679_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This was a retrospective review of 36 patients who underwent endoscopic carbon dioxide laser surgery for T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> glottic cancer. Post-operative, endoscopic examinations were rated by three blinded otolaryngologists for time to heal and presence of granulation. Patient and surgical factors were compared with time to heal and granulation.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121004679_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 16 of 36 wounds (44 per cent) developed granulation tissue, and 24 wounds (67 per cent) healed without requiring surgical intervention. A total of 7 of 8 wounds biopsied more than 3.5 months after surgery had persistent cancer versus 1 of 4 wounds biopsied at equal to or less than 3.5 months (85.7 per cent <jats:italic>vs<\/jats:italic> 25 per cent; <jats:italic>p =<\/jats:italic> 0.03). Biopsy at more than 3.5 months was associated with 28-fold increased odds of cancer in biopsy compared with biopsy at equal to or less than 3.5 months (odds ratio, 28.0; 95 per cent confidence interval, 1.088\u2013373.3).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215121004679_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>After carbon dioxide laser surgery for glottic cancer, development of granulation tissue is common. Granulation that persists for more than 3.5 months necessitates biopsy because of increased risk of persistent cancer.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215121004679","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T07:40:39Z","timestamp":1643614839000},"page":"205-212","source":"Crossref","is-referenced-by-count":2,"title":["Healing after transoral carbon dioxide laser surgery for early glottic cancer"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-8879","authenticated-orcid":false,"given":"N","family":"Jabbour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L F","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"S0022215121004679_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22492"},{"key":"S0022215121004679_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21284"},{"key":"S0022215121004679_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02726-3"},{"key":"S0022215121004679_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116009798"},{"key":"S0022215121004679_ref9","first-page":"1","article-title":"A comparison of consensus, consistency, and measurement approaches to estimating interrater reliability","volume":"9","author":"Stemler","year":"2004","journal-title":"Pract Assess Res Eval"},{"key":"S0022215121004679_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.09.012"},{"key":"S0022215121004679_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-1034-7"},{"key":"S0022215121004679_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.1.59"},{"key":"S0022215121004679_ref1","first-page":"381","article-title":"Oncologic and voice outcomes after treatment of early glottic cancer: transoral laser microsurgery versus radiotherapy","volume":"41","author":"Kerr","year":"2012","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"S0022215121004679_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000057"},{"key":"S0022215121004679_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24080"},{"key":"S0022215121004679_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215115000444"},{"key":"S0022215121004679_ref10","doi-asserted-by":"publisher","DOI":"10.1037\/a0015808"},{"key":"S0022215121004679_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-162"},{"key":"S0022215121004679_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20009"},{"key":"S0022215121004679_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.07.002"},{"key":"S0022215121004679_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0003489417749253"},{"key":"S0022215121004679_ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071419"},{"key":"S0022215121004679_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27283"},{"key":"S0022215121004679_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199803000-00012"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215121004679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T10:10:25Z","timestamp":1677060625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215121004679\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0022215121004679"],"URL":"https:\/\/doi.org\/10.1017\/s0022215121004679","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,31]]}}}