{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:46:52Z","timestamp":1776484012611,"version":"3.51.2"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215122000366_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laryngeal dysplasia represents a complex pre-malignant condition characterised by a spectrum of mucosal changes, with a reported malignant transformation rate from dysplasia to invasive carcinoma of 14.0 per cent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215122000366_sec_a2\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify whether increasing glottic dysplasia severity is associated with higher local malignant transformation rates or adverse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215122000366_sec_a3\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study identified 125 patients with any histopathological grade of glottic dysplasia over a 10-year period who were followed up for a standardised 10-year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215122000366_sec_a4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The malignant transformation rate was 21.8 per cent over 10 years, demonstrating a statistically significant greater risk with increasing dysplasia severity. The mean time to transformation was 52 months, with time to transformation statistically associated with increasing dysplasia severity. Rapid progression to carcinoma within 12 months occurred in 40 per cent of cases, and 58 per cent of subsequently diagnosed laryngeal squamous cell carcinomas were tumour stage T\n                      <jats:sub>1<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215122000366_sec_a5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Laryngeal dysplasia carries a significant malignant potential, appearing greatest within 12 months of diagnosis and with increasing severity of dysplasia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215122000366","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T21:47:20Z","timestamp":1645134440000},"page":"547-553","source":"Crossref","is-referenced-by-count":2,"title":["Laryngeal dysplasia: a 10-year review of rates of progression to invasive carcinoma and treatment-specific outcomes in a regional ENT department in Northern Ireland"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-070X","authenticated-orcid":false,"given":"G","family":"Donaldson","sequence":"first","affiliation":[{"name":"Royal Victoria Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"McCadden","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Napier","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T J","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"S0022215122000366_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04169.x"},{"key":"S0022215122000366_ref4","doi-asserted-by":"publisher","DOI":"10.1044\/2014_JSLHR-S-13-0283"},{"key":"S0022215122000366_ref19","volume-title":"Cancer Incidence Trends 1993-2013 with Projections to 2035","author":"Donnelly","year":"2016"},{"key":"S0022215122000366_ref15","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2020.1730437"},{"key":"S0022215122000366_ref13","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours","author":"Barnes","year":"2005"},{"key":"S0022215122000366_ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1253572"},{"key":"S0022215122000366_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00859.x"},{"key":"S0022215122000366_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1684-x"},{"key":"S0022215122000366_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0788-z"},{"key":"S0022215122000366_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1013-9"},{"key":"S0022215122000366_ref14","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0438-RA"},{"key":"S0022215122000366_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis698"},{"key":"S0022215122000366_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2982"},{"key":"S0022215122000366_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2010.02119.x"},{"key":"S0022215122000366_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2010.02181.x"},{"key":"S0022215122000366_ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.023"},{"key":"S0022215122000366_ref12","volume-title":"World Health Organization Classification of Tumours: WHO Classification of Head and Neck Tumours","volume":"9","author":"El-Naggar","year":"2017"},{"key":"S0022215122000366_ref6","first-page":"957","article-title":"Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study","volume":"13","author":"Talamini","year":"2002","journal-title":"Cancer Causes Control"},{"key":"S0022215122000366_ref22","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700114"},{"key":"S0022215122000366_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814525749"},{"key":"S0022215122000366_ref20","volume-title":"National Joint Registry for England, Wales, Northern Ireland and the Isle of Man: 15th Annual Report 2018","year":"2018"},{"key":"S0022215122000366_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.3736"},{"key":"S0022215122000366_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.296"},{"key":"S0022215122000366_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2670-2"}],"container-title":["The Journal of Laryngology &amp; 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