{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:23:56Z","timestamp":1793215436262,"version":"4.5.0"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Infectious mononucleosis is a relatively common acute presentation to the ENT department. There is an expected derangement in the liver function test results in most patients. There is no guidance regarding follow up, and practice varies. This study aimed to evaluate the utility of liver function tests and abdominal ultrasound in infectious mononucleosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective study of all adult patients admitted under ENT with infectious mononucleosis over a five-year period.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 153 patients were included; 80 per cent had abnormal liver function test results at presentation. Around 50 per cent had at least one liver function test assessment following discharge. Median (interquartile range) time to resolution of liver function test results was 32 days (20\u201350 days); maximum time was 10 months. Six patients had in-patient abdominal ultrasound: all showed a normal liver and biliary tree. No patient developed any liver disease sequelae.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The findings suggest that serial assessment of liver function is not required in immunocompetent adults with subclinical derangement in liver function.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122000639","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T01:18:42Z","timestamp":1650849522000},"page":"319-322","source":"Crossref","is-referenced-by-count":4,"title":["Infectious mononucleosis \u2013 should we routinely assess liver function in acute presentation and follow up?"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-6604","authenticated-orcid":false,"given":"L","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Saman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Edafe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"S0022215122000639_ref7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejim.2010.07.016","article-title":"Epstein Barr virus hepatitis","volume":"22","author":"Kofteridis","year":"2011","journal-title":"Eur J Intern Med"},{"key":"S0022215122000639_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100099680"},{"key":"S0022215122000639_ref2","unstructured":"2 Infectious mononucleosis. In: https:\/\/bestpractice.bmj.com\/topics\/en-gb\/123 [6 October 2020]"},{"key":"S0022215122000639_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-019-0954-3"},{"key":"S0022215122000639_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3029-2"},{"key":"S0022215122000639_ref3","doi-asserted-by":"crossref","first-page":"h1825","DOI":"10.1136\/bmj.h1825","article-title":"Infectious mononucleosis","volume":"350","author":"Lennon","year":"2015","journal-title":"BMJ"},{"key":"S0022215122000639_ref6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3350\/cmh.2013.19.4.382","article-title":"The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children","volume":"19","author":"Wang","year":"2013","journal-title":"Clin Mol Hepatol"},{"key":"S0022215122000639_ref5","first-page":"372","article-title":"Common questions about infectious mononucleosis","volume":"91","author":"Womack","year":"2015","journal-title":"Am Fam Physician"},{"key":"S0022215122000639_ref8","first-page":"234","article-title":"Prospective study of the natural history of infectious mononucleosis caused by Epstein-Barr virus","volume":"14","author":"Rea","year":"2001","journal-title":"J Am Board Fam Pract"},{"key":"S0022215122000639_ref10","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0208-RA"},{"key":"S0022215122000639_ref1","unstructured":"1 Glandular fever (infectious mononucleosis). In: https:\/\/cks.nice.org.uk\/topics\/glandular-fever-infectious-mononucleosis\/ [15 July 2021]"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215122000639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T12:47:37Z","timestamp":1677588457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215122000639\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,25]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0022215122000639"],"URL":"https:\/\/doi.org\/10.1017\/s0022215122000639","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,25]]}}}