{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:16:24Z","timestamp":1758273384002,"version":"3.40.5"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122000652_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Heat from transoral laser microsurgery can cause tissue shrinkage, impacting the surgical margin. This study aimed to compare shrinkage between cold steel and carbon dioxide laser resections of laryngeal lesions.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122000652_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A European Laryngological Society type II resection was performed on 10 mm \u2018lesions\u2019 marked on both the true and false folds of fresh-frozen human larynxes; specifically, laser resection was performed on the right side and cold steel resection on the left side.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122000652_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Twenty-eight larynxes were included. Tissue shrinkage was significantly higher in laser resection (35\u201345 per cent) compared to cold steel resection (8\u201314 per cent) (<jats:italic>p<\/jats:italic> &lt; 0.0001). In most cases, there was no significant difference in shrinkage between true and false fold sites.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122000652_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that specimen shrinkage is significantly higher in laser resections. This shrinkage will affect the size of the surgical margin; surgeons and pathologists should be aware of this when considering positive and close margins.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122000652","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:56:50Z","timestamp":1646211410000},"page":"1265-1270","source":"Crossref","is-referenced-by-count":2,"title":["Quantifying the shrinkage of laryngeal laser excisions: a case control study"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8840-9454","authenticated-orcid":false,"given":"E","family":"Halliday","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"S0022215122000652_ref4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4103\/0974-2077.58519","article-title":"Carbon dioxide laser guidelines","volume":"2","author":"Shankar","year":"2009","journal-title":"J Cutan Aesthet Surg"},{"key":"S0022215122000652_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050228"},{"key":"S0022215122000652_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/000348946807700602"},{"key":"S0022215122000652_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.10"},{"key":"S0022215122000652_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20285"},{"key":"S0022215122000652_ref10","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/35\/1\/55"},{"key":"S0022215122000652_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2317-8"},{"key":"S0022215122000652_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12807"},{"key":"S0022215122000652_ref19","first-page":"32","article-title":"Impact of low-thermal-injury devices on margin status in laryngeal cancer","volume":"50","author":"Mannelli","year":"2014","journal-title":"An experimental ex vivo study. Oral Oncol"},{"key":"S0022215122000652_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-2746(99)90157-X"},{"key":"S0022215122000652_ref14","first-page":"29","article-title":"The effect of the surgical margins on the outcome of patients with head and neck squamous cell carcinoma: single institution experience","volume":"9","author":"Eldeeb","year":"2012","journal-title":"Cancer Biol Med"},{"key":"S0022215122000652_ref3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030732"},{"key":"S0022215122000652_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/BF02478228"},{"key":"S0022215122000652_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199111000-00010"},{"key":"S0022215122000652_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2012.02.006"},{"key":"S0022215122000652_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70173-D"},{"key":"S0022215122000652_ref1","unstructured":"1 Cancer Research UK. What is laryngeal cancer? 2018. In: https:\/\/www.cancerresearchuk.org\/about-cancer\/laryngeal-cancer\/what-is-laryngeal-cancer [3 August 2021]"},{"key":"S0022215122000652_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199707)19:4<281::AID-HED6>3.0.CO;2-X"},{"key":"S0022215122000652_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198602000-00011"},{"key":"S0022215122000652_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2007.01337.x"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215122000652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T08:32:27Z","timestamp":1669278747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215122000652\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0022215122000652"],"URL":"https:\/\/doi.org\/10.1017\/s0022215122000652","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"type":"print","value":"0022-2151"},{"type":"electronic","value":"1748-5460"}],"subject":[],"published":{"date-parts":[[2022,3,2]]}}}