{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:14:29Z","timestamp":1784693669059,"version":"3.55.0"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122000706_sec_a1\"><jats:title>Background<\/jats:title><jats:p>This paper reports a case series of three elderly patients who were regularly attending ENT clinic every four to six weeks for ear canal care to address chronic otitis externa. All three patients had been taking bisphosphonate alendronic acid for years, and it is suspected that this drug was partly to blame for the progression of their chronic ear conditions.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122000706_sec_a2\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Some improvements were noted when the bisphosphonate was discontinued. The regular microsuctioning, and application of topical antibiotics with steroids, provided temporary relief of symptoms. The present pandemic shut down the routine clinic and the patients were not seen for four to five months. On latest review, it was a surprise to see that their ears seemed to have significantly improved, with healthy re-epithelialisation.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122000706_sec_a3\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>It is thus believed that excessive and repeated microsuctioning in bisphosphonate-induced osteonecrosis of that external ear canal can delay re-epithelialisation, and gradually prolonging the intervals between microsuctioning could help in overall resolution of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122000706","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T01:15:26Z","timestamp":1649207726000},"page":"1002-1004","source":"Crossref","is-referenced-by-count":5,"title":["Give ears some respite from regular microsuctioning in bisphosphonate-induced osteonecrosis of the external ear canal"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-2882","authenticated-orcid":false,"given":"E","family":"Abelardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jaramillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"S0022215122000706_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118000324"},{"key":"S0022215122000706_ref2","unstructured":"2 Side effects for all bisphosphonates. In: https:\/\/bnf.nice.org.uk\/drug\/alendronic-acid.html#sideEffects [27 September 2020]"},{"key":"S0022215122000706_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"S0022215122000706_ref10","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1056\/NEJMp1202619","article-title":"Bisphosphonates for osteoporosis \u2013 where do we go from here?","volume":"366","author":"Whitaker","year":"2012","journal-title":"N Engl J Med"},{"key":"S0022215122000706_ref6","unstructured":"6 International Classification of Diseases 11th Revision. In: https:\/\/www.who.int\/classifications\/icd\/en\/ [17 October 2020]"},{"key":"S0022215122000706_ref9","first-page":"3","article-title":"Bisphosphonate-induced osteonecrosis of the external auditory canal: a case report","volume":"2","author":"Thorasteinsson","year":"2015","journal-title":"J Clin Med Case Reports"},{"key":"S0022215122000706_ref5","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1210\/jc.2012-1027","article-title":"Benefits and risks of bisphosphonate therapy for osteoporosis","volume":"97","author":"Khosla","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"S0022215122000706_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31827ca34d"},{"key":"S0022215122000706_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1496-z"},{"key":"S0022215122000706_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2684-7"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215122000706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T09:44:20Z","timestamp":1664271860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215122000706\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0022215122000706"],"URL":"https:\/\/doi.org\/10.1017\/s0022215122000706","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]}}}