{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:53:02Z","timestamp":1747173182310,"version":"3.40.5"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122001153_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Abnormal gains in six-canal video head impulse test are attributed to semi-circular canal deficits. However, as video head impulse test responses are linked to the vestibulo-ocular reflex, it was hypothesised that abnormal gains can be caused by vestibulo-ocular reflex pathway deficits.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001153_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This study compared video head impulse test gains in 20 patients with superior semi-circular canal dehiscence (labyrinthine cause) and 20 side- and gender-matched patients with vestibular schwannomas (retrolabyrinthine cause), and investigated correlations between them (Mann\u2013Kendall trend test).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001153_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Vestibular schwannoma but not superior semi-circular canal dehiscence was significantly associated with abnormal lateral (odds ratio = 9.00 (95 per cent confidence interval = 1.638\u201349.44), <jats:italic>p<\/jats:italic> = 0.011) and posterior (odds ratio = 9.00 (95 per cent confidence interval = 2.151\u201337.659), <jats:italic>p<\/jats:italic> = 0.003) canal status. In vestibular schwannoma patients, there was a statistically significant degree of dependence between all ipsilesional canal video head impulse test gains; such dependence was not observed in superior semi-circular canal dehiscence.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001153_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Vestibulo-ocular reflex gains differ in patients with labyrinthine and retrolabyrinthine disease; this suggests that abnormal gains can indicate deficits not only in the semi-circular canals but also elsewhere along the vestibulo-ocular reflex pathway.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122001153","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T07:13:09Z","timestamp":1652685189000},"page":"398-403","source":"Crossref","is-referenced-by-count":1,"title":["Six-canal video head impulse test in patients with labyrinthine and retrolabyrinthine pathology: detecting vestibulo-ocular reflex deficits"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-1661","authenticated-orcid":false,"given":"G","family":"Kontorinis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-3283","authenticated-orcid":false,"given":"H","family":"Tailor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Tikka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A M","family":"Slim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"S0022215122001153_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31828d676d"},{"key":"S0022215122001153_ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00258"},{"key":"S0022215122001153_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g283"},{"key":"S0022215122001153_ref8","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000299117.48935.2e"},{"key":"S0022215122001153_ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000358002"},{"key":"S0022215122001153_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/BF02423496"},{"key":"S0022215122001153_ref6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bacf85"},{"key":"S0022215122001153_ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061488"},{"key":"S0022215122001153_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3042-2"},{"key":"S0022215122001153_ref19","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1185540"},{"key":"S0022215122001153_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13470"},{"key":"S0022215122001153_ref15","doi-asserted-by":"publisher","DOI":"10.5152\/JIAO.2021.8572"},{"key":"S0022215122001153_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107001028"},{"key":"S0022215122001153_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.001"},{"key":"S0022215122001153_ref1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000175987.59991.3d"},{"key":"S0022215122001153_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03730.x"},{"key":"S0022215122001153_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520310043015"},{"key":"S0022215122001153_ref12","unstructured":"12 GN Otometrics A\/S. 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