{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:53:03Z","timestamp":1747173183327,"version":"3.40.5"},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122001311_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Tongue base mucosectomy identified cancer in 78 per cent of cancers of unknown primary in a recent meta-analysis. The carbon dioxide laser is an alternative technique if there is no access to a robot. This study aimed to describe the steps for undertaking tongue base mucosectomy using the carbon dioxide laser and its diagnostic utility in cancers of unknown primary.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001311_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This was a prospective feasibility study utilising carbon dioxide laser for tongue base mucosectomy in cancers of unknown primary. Data collected included demographic data and p16 status.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001311_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There were 14 cancers of unknown primary with 86 per cent p16 positivity on immunohistochemistry. Laser tongue base mucosectomy alone identified the cancer primary in 7 of 12 (58 per cent) cancers of unknown primary among p16 positive tumours and 0 of 2 (0 per cent) among p16 negative tumours. Combining bilateral tonsillectomy with laser tongue base mucosectomy resulted in identification of the primary cancer in 8 of 12 (67 per cent) p16 positive tumours.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001311_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>In centres without a robot, tongue base mucosectomy using the carbon dioxide laser is a viable alternative, especially in combination with bilateral tonsillectomy in p16 positive cases.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122001311","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T09:26:01Z","timestamp":1654680361000},"page":"438-441","source":"Crossref","is-referenced-by-count":2,"title":["Laser tongue base mucosectomy is a useful diagnostic tool in the management of unknown primary cancers of the head and neck region"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3168-2556","authenticated-orcid":false,"given":"O","family":"Olaleye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Nassif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"S0022215122001311_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21898"},{"key":"S0022215122001311_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21743"},{"key":"S0022215122001311_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23372"},{"key":"S0022215122001311_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.02.018"},{"key":"S0022215122001311_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12860"},{"key":"S0022215122001311_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23562"},{"key":"S0022215122001311_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23800"},{"key":"S0022215122001311_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24705"},{"key":"S0022215122001311_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000591"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215122001311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T11:01:35Z","timestamp":1679655695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215122001311\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,8]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0022215122001311"],"URL":"https:\/\/doi.org\/10.1017\/s0022215122001311","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"type":"print","value":"0022-2151"},{"type":"electronic","value":"1748-5460"}],"subject":[],"published":{"date-parts":[[2022,6,8]]}}}