{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:29:48Z","timestamp":1793410188427,"version":"4.5.0"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122001682_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the long-term functional outcomes in patients who received primary radiotherapy for tumour\u2013node stage T<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub> glottic carcinoma, stratified for tumour extension.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001682_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A cross-sectional study was performed on patients who were treated with radiotherapy for T<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub> glottic carcinoma. Four questionnaires were used to measure different aspects of functional outcome. In addition, objective evaluation and perceptual analysis were performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001682_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Fourteen patients were included in this study. The median time between the start of radiotherapy and assessment was 42 months (range, 26\u2013143 months). Patients reported high-level functioning, with low symptom scores and good swallowing function, and showed a median dysphonia grade of 1.5. The median Voice Handicap Index-30 score was 17.5.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001682_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Patients with T<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub> glottic carcinoma treated with radiotherapy had good long-term quality of life, with low symptom scores, good swallowing functioning and slightly elevated voice outcome parameters.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122001682","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T05:31:53Z","timestamp":1658727113000},"page":"685-690","source":"Crossref","is-referenced-by-count":5,"title":["Long-term functional outcomes in tumour stage T<sub>2<\/sub> glottic carcinoma after radiotherapy"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-8842","authenticated-orcid":false,"given":"M","family":"Hendriksma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B J","family":"Heijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B M","family":"Verbist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A P M","family":"Langeveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P P G","family":"van Benthem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E V","family":"Sj\u00f6gren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"S0022215122001682_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2018.11.007"},{"key":"S0022215122001682_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"S0022215122001682_ref15","first-page":"237","article-title":"Measure voices with Praat [in Dutch]","volume":"12","author":"Boersma","year":"2004","journal-title":"Stem Spr Taalpathologie"},{"key":"S0022215122001682_ref10","doi-asserted-by":"publisher","DOI":"10.3109\/02841869409098450"},{"key":"S0022215122001682_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-011-9327-3"},{"key":"S0022215122001682_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.09.019"},{"key":"S0022215122001682_ref18","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400801"},{"key":"S0022215122001682_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00186-6"},{"key":"S0022215122001682_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.10.018"},{"key":"S0022215122001682_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000438"},{"key":"S0022215122001682_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.11.004"},{"key":"S0022215122001682_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12139"},{"key":"S0022215122001682_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.09.016"},{"key":"S0022215122001682_ref14","volume-title":"Clinical Examination of Voice","author":"Hirano","year":"1981"},{"key":"S0022215122001682_ref17","volume-title":"The TNM Classification of Malignant Tumours","author":"Brierley","year":"2016"},{"key":"S0022215122001682_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s004050000307"},{"key":"S0022215122001682_ref8","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"S0022215122001682_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20625"},{"key":"S0022215122001682_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21783"},{"key":"S0022215122001682_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23603"},{"key":"S0022215122001682_ref11","first-page":"870","article-title":"The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer","volume":"127","author":"Chen","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"S0022215122001682_ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000127836"},{"key":"S0022215122001682_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2460-x"},{"key":"S0022215122001682_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20750"}],"container-title":["The Journal of Laryngology &amp; 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