{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:36:22Z","timestamp":1771652182741,"version":"3.50.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122001724_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>The extent of parotidectomy in the management of regional metastatic disease is controversial. This systematic review aimed to appraise data from studies evaluating superficial and total parotidectomy in metastatic cutaneous squamous cell carcinoma and cutaneous malignant melanoma of the head and neck.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001724_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>A systematic search of PubMed, Embase and Cochrane Library was performed. The protocol was registered with Prospero (CRD42020217962).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001724_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of five studies evaluated cutaneous malignant melanoma. Only one compared outcomes of superficial and total parotidectomy: they found higher parotid area recurrence following superficial parotidectomy. Seven studies reported outcomes following cutaneous squamous cell carcinoma; some studies found higher regional recurrence and reduced survival in total parotidectomy, but there was likely selection bias in these studies. Others found no difference in survival between superficial and total parotidectomy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001724_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>The effect of the extent of parotidectomy on outcomes is unclear in cutaneous malignant melanoma and cutaneous squamous cell carcinoma. This systematic review highlights the need for well-designed studies to direct better care.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122001724","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T09:08:58Z","timestamp":1659344938000},"page":"592-598","source":"Crossref","is-referenced-by-count":2,"title":["Superficial versus total parotidectomy for metastatic cutaneous squamous cell carcinoma and melanoma of the head and neck: a systematic review"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-1348","authenticated-orcid":false,"given":"W S","family":"Leong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Gowda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-4336","authenticated-orcid":false,"given":"R","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Chabrillac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Edafe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"S0022215122001724_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24810"},{"key":"S0022215122001724_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.352"},{"key":"S0022215122001724_ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997856"},{"key":"S0022215122001724_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.09.011"},{"key":"S0022215122001724_ref16","first-page":"28","article-title":"The role of parotidectomy in the treatment of nodal metastases from cutaneous melanoma of the head and neck","volume":"16","author":"Vaglini","year":"1990","journal-title":"Eur J Surg Oncol"},{"key":"S0022215122001724_ref22","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814520686"},{"key":"S0022215122001724_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000554"},{"key":"S0022215122001724_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06191-5"},{"key":"S0022215122001724_ref25","first-page":"00012","article-title":"Comparison of the effect of total conservative parotidectomy versus superficial parotidectomy in management of benign parotid gland tumor: a systematic review","author":"Fol HA","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"S0022215122001724_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000852"},{"key":"S0022215122001724_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100133006"},{"key":"S0022215122001724_ref9","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1007\/s00405-016-4173-4","article-title":"Long-term effects of parotidectomy","volume":"273","author":"Kaya","year":"2016","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"S0022215122001724_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.4219"},{"key":"S0022215122001724_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-10-117"},{"key":"S0022215122001724_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20417"},{"key":"S0022215122001724_ref15","first-page":"318","article-title":"Surgical procedures for primary, metastatic or adjacent parotid tumours","volume":"84","author":"Martins","year":"1999","journal-title":"Int Surg"},{"key":"S0022215122001724_ref10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0196-0709(96)90004-6","article-title":"Metastasis to the parotid gland: is a radical surgical approach justified","volume":"17","author":"Jecker","year":"1996","journal-title":"Am J Otolaryngol"},{"key":"S0022215122001724_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06574-8"},{"key":"S0022215122001724_ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2017-110853"},{"key":"S0022215122001724_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24496"},{"key":"S0022215122001724_ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818764348"},{"key":"S0022215122001724_ref21","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000173202.56739.9f"},{"key":"S0022215122001724_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25670"},{"key":"S0022215122001724_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790060038010"},{"key":"S0022215122001724_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2021.100024"}],"container-title":["The Journal of Laryngology &amp; 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