{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:42:26Z","timestamp":1765888946455,"version":"3.40.5"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122001803_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>The objective of this systematic review and meta-analysis was to evaluate the role of doxycycline in the management of chronic rhinosinusitis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001803_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This was a systematic review using Ovid Medline, Cinahl, Scopus and Cochrane and was limited to meta-analyses, systematic reviews and randomised, clinical trials. A combination of the following search terms was used: \u2018sinusitis\u2019, \u2018nasal polyps\u2019, \u2018doxycycline\u2019 and \u2018tetracycline\u2019. Raw means and standard deviations were extracted from the included studies. The meta-analysis was performed using mean differences of pre- versus post-doxycycline treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001803_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 279 studies were screened, of which 5 studies met the criteria (all randomised, controlled trials published between 2010 and 2021). The interventions, endpoints and measured outcomes varied across all studies. Meta-analysis performed on pre- versus post-doxycycline treatment for Sino-Nasal Outcome Test-22, nasal polyp scores and symptom scores did not yield statistically significant results.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122001803_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>This review identified a small number of high-quality studies on the use of doxycycline in chronic rhinosinusitis. There does not seem to be convincing evidence for the routine use of doxycycline in patients with chronic rhinosinusitis. Further research may try to identify certain phenotypes of chronic rhinosinusitis that may better respond to doxycycline.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122001803","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T06:04:05Z","timestamp":1659506645000},"page":"474-483","source":"Crossref","is-referenced-by-count":7,"title":["A systematic review and meta-analysis of the role of doxycycline in chronic rhinosinusitis"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-906X","authenticated-orcid":false,"given":"D","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"S0022215122001803_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.61"},{"key":"S0022215122001803_ref1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.401"},{"key":"S0022215122001803_ref15","first-page":"559","article-title":"The clinical outcomes of medical therapies in chronic rhinosinusitis are independent of microbiomic outcomes: a double-blinded, randomised placebo-controlled trial","volume":"58","author":"Cherian","year":"2020","journal-title":"Rhinology"},{"key":"S0022215122001803_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.056"},{"key":"S0022215122001803_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01188-y"},{"key":"S0022215122001803_ref4","first-page":"S99","article-title":"Canadian clinical practice guidelines for acute and chronic rhinosinusitis","volume":"40","author":"Desrosiers","year":"2011","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"S0022215122001803_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.009"},{"key":"S0022215122001803_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.02.020"},{"key":"S0022215122001803_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215113000558"},{"key":"S0022215122001803_ref6","first-page":"CD011994","article-title":"Systemic and topical antibiotics for chronic rhinosinusitis","volume":"4","author":"Head","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"S0022215122001803_ref19","doi-asserted-by":"publisher","DOI":"10.4103\/2229-3485.159943"},{"key":"S0022215122001803_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22799"},{"key":"S0022215122001803_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60856-3"},{"key":"S0022215122001803_ref5","first-page":"500","article-title":"Chronic rhinosinusitis","volume":"96","author":"Sedaghat","year":"2017","journal-title":"Am Fam Physician"},{"key":"S0022215122001803_ref12","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino15.291"},{"key":"S0022215122001803_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0690-5"},{"key":"S0022215122001803_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7544"},{"key":"S0022215122001803_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.03.004"},{"key":"S0022215122001803_ref9","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4103\/0019-5154.190105","article-title":"Anti-inflammatory and immunomodulatory effects of antibiotics and their use in dermatology","volume":"61","author":"Pradhan","year":"2016","journal-title":"Indian J Dermatol"},{"key":"S0022215122001803_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.01.019"},{"key":"S0022215122001803_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2019.12.005"},{"key":"S0022215122001803_ref2","doi-asserted-by":"publisher","DOI":"10.21037\/ajo.2018.01.03"},{"key":"S0022215122001803_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"}],"container-title":["The Journal of Laryngology &amp; 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