{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:43:20Z","timestamp":1785807800760,"version":"3.56.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122002262_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>Bilateral M\u00e9ni\u00e8re's disease is classified according to the time of appearance of symptoms in each ear into synchronous and metachronous types. A descriptive longitudinal study, involving 59 bilateral M\u00e9ni\u00e8re's disease patients, was carried out to assess the two forms of bilateral M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002262_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Data on symptomatic chronology in each ear, auditory evolution and evolution of vertiginous crisis, among other aspects, were obtained, analysed and compared. Possible risk factors for M\u00e9ni\u00e8re's disease becoming bilateral were analysed after conducting nested case\u2013control studies in a cohort.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002262_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The metachronous form was seen in 76.3 per cent of cases, and the time it took for the disease to become bilateral took a median time of seven years. The symptomatic triad was the most frequent symptomatic debut for the first ear in both forms. Synchronous debut presented a greater average hearing loss. Suffering from migraine and a symptomatic onset with a greater number of symptoms appear to be possible predictors of conversion to bilateral M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002262_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Bilateral M\u00e9ni\u00e8re's disease temporal models presented differences. The study of them helps to better understand, prevent and predict the behaviour of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122002262","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T12:45:43Z","timestamp":1665060343000},"page":"782-788","source":"Crossref","is-referenced-by-count":9,"title":["Bilateral M\u00e9ni\u00e8re's disease according to its form of debut: synchronous and metachronous disease"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2884-5251","authenticated-orcid":false,"given":"T","family":"P\u00e9rez-Carbonell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Orts-Alborch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Pla-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"P\u00e9rez-Guil\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Ten\u00edas-Burrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Marco-Algarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"P\u00e9rez-Garrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"S0022215122002262_ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00303"},{"key":"S0022215122002262_ref16","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609124348"},{"key":"S0022215122002262_ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00182"},{"key":"S0022215122002262_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2015.05.005"},{"key":"S0022215122002262_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800603"},{"key":"S0022215122002262_ref1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-150549"},{"key":"S0022215122002262_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0515-z"},{"key":"S0022215122002262_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31826426b9"},{"key":"S0022215122002262_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283304cb3"},{"key":"S0022215122002262_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200408000-00010"},{"key":"S0022215122002262_ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.674170"},{"key":"S0022215122002262_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816628524"},{"key":"S0022215122002262_ref3","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903382808"},{"key":"S0022215122002262_ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000331945"},{"key":"S0022215122002262_ref11","first-page":"265","article-title":"Informatics program in the study of patients with M\u00e9ni\u00e8re's vertigo","volume":"19","author":"P\u00e9rez-Garrigues","year":"1992","journal-title":"An Otorrinolaringol Ibero Am"},{"key":"S0022215122002262_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200604000-00011"},{"key":"S0022215122002262_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00028-2"},{"key":"S0022215122002262_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.4.431"},{"key":"S0022215122002262_ref17","doi-asserted-by":"publisher","DOI":"10.1080\/00016480802112587"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215122002262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T08:09:10Z","timestamp":1689149350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215122002262\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0022215122002262"],"URL":"https:\/\/doi.org\/10.1017\/s0022215122002262","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]}}}