{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:06:54Z","timestamp":1769000814503,"version":"3.49.0"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122002419_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This study was a systematic review to investigate the progression of untreated obstructive sleep apnoea in order to evaluate whether mild obstructive sleep apnoea should be treated from the standpoint of disease progression.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002419_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>The database search study outcomes that were collected included Apnea Hypopnea Index and Respiratory Disturbance Index. A meta-analysis of obstructive sleep apnoea severity over time intervals was performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002419_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 17 longitudinal studies and 1 randomised, controlled trial were included for review. For patients with mild obstructive sleep apnoea, mean pre-study and post-study Apnea Hypopnea Index was 5.21 and 8.03, respectively, over a median interval of 53.1 months. In patients with moderate to severe obstructive sleep apnoea, mean pre-study and post-study Apnea Hypopnea Index was 28.9 and 30.3, respectively, over a median interval of 57.8 months. Predictors for disease progression in mild obstructive sleep apnoea are patients aged less than 60 years and those with a baseline body mass index less than 25.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002419_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Mild obstructive sleep apnoea progression is observed, but it does not appear to reach any clinically significant progression to moderate or severe obstructive sleep apnoea.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122002419","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T05:38:19Z","timestamp":1668577099000},"page":"828-839","source":"Crossref","is-referenced-by-count":2,"title":["Should mild obstructive sleep apnoea be treated? 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