{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:53:15Z","timestamp":1747173195562,"version":"3.40.5"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215122002468_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to discuss the role of large cavity functional endoscopic sinus surgery in the management of chronic rhinosinusitis with nasal polyps in patients with non-steroidal anti-inflammatory drug exacerbated respiratory disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002468_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This was a retrospective review of patients undergoing large cavity functional endoscopic sinus surgery for non-steroidal anti-inflammatory drug exacerbated respiratory disease from January 2016 to March 2022. Population characteristics, pre- and post-operative number of functional endoscopic sinus surgical procedures, endoscopic polyp grade, Lund\u2013Mackay score and nasal symptoms were recorded.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002468_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Thirteen consecutive patients with a median age of 47 years were included. They all failed maximal medical treatment and\/or conservative functional endoscopic sinus surgery and underwent large cavity sinus surgery followed by post-operative maximal medical therapy. All patients showed an improvement in nasal symptoms with improved Lund\u2013Mackay scores post-operatively. The median length of follow up was 1.5 years.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002468_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Large cavity functional endoscopic sinus surgery seems to halt the progression of chronic rhinosinusitis with nasal polyps in non-steroidal anti-inflammatory drug exacerbated respiratory disease. In this case series, large cavity functional endoscopic sinus surgery combined with optimal post-operative medical treatment appeared to switch off chronic rhinosinusitis with nasal polyps in patients with non-steroidal anti-inflammatory drug exacerbated respiratory disease.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122002468","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T05:24:31Z","timestamp":1669699471000},"page":"883-889","source":"Crossref","is-referenced-by-count":3,"title":["The role of large cavity sinus surgery in the management of chronic rhinosinusitis in non-steroidal anti-inflammatory drug exacerbated respiratory disease: a single-centre experience and long-term outcomes"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-5303","authenticated-orcid":false,"given":"A 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