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Secondary post-tonsillectomy haemorrhage occurring more than 24 hours after an operation has long been attributed to post-operative infection; however, there is little evidence to support this hypothesis and the associated use of antibiotics in the current literature.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002547_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This study looked at the aetiology and evidence-based management of post-tonsillectomy haemorrhage, and investigated the impact of bacterial infection and antimicrobials on the pathogenesis and clinical course of this complication.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002547_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A number of peri-operative risk factors for post-tonsillectomy haemorrhage exist, and infective pathologies, including recurrent or chronic tonsillitis and group A streptococcus on blood cultures, may predispose to bleeding. Very few studies have shown a link between post-tonsillectomy haemorrhage and objective markers of infection such as pyrexia, raised inflammatory markers or positive microbiology cultures. The role of antibiotics in secondary post-tonsillectomy haemorrhage remains controversial, and numerous randomised, controlled trials of peri-operative antibiotics have shown no significant difference in bleeding rates between antibiotics and controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215122002547_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Further trials investigating the role of antibiotics and more robust studies investigating the presence of bacterial infection at the time of bleeding may be required to determine the true role of infection in post-tonsillectomy haemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215122002547","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T09:51:07Z","timestamp":1670925067000},"page":"710-717","source":"Crossref","is-referenced-by-count":3,"title":["Does infection play a role in post-tonsillectomy haemorrhage? 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