{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:53:22Z","timestamp":1747173202269,"version":"3.40.5"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215123000348_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of surgical intervention on serum insulin-like growth factor 1 levels in patients with obstructive sleep apnoea.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123000348_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted in a tertiary care hospital of adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy failed or was refused. All patients underwent polysomnography and serum insulin-like growth factor 1 evaluation pre-operatively and at three months post-operatively. The site of surgery was determined using M\u00fcller's manoeuvre and ApneaGraph AG 200.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123000348_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Fifteen patients were included with a mean age of 38 years: 11 males and 4 females. The mean pre-operative Apnoea\u2013Hypopnoea Index using polysomnography was 53.7 events per hour, and the mean post-operative Apnoea\u2013Hypopnoea Index at three months was 15.3 events per hour (<jats:italic>p<\/jats:italic> = 0.0001). The mean pre-operative serum insulin-like growth factor 1 was 160.2 \u03bcg\/l, while the mean post-operative value was 236.98 \u03bcg\/l (<jats:italic>p<\/jats:italic> = 0.005).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123000348_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>In adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy fails, site-specific surgical intervention to treat the obstruction leads to an increase in serum insulin-like growth factor 1 levels.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215123000348","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T08:40:26Z","timestamp":1678092026000},"page":"1222-1225","source":"Crossref","is-referenced-by-count":0,"title":["Effect of surgical intervention on serum insulin-like growth factor 1 in patients with obstructive sleep apnoea"],"prefix":"10.1017","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7419-2015","authenticated-orcid":false,"given":"A S","family":"Jaiswal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B V","family":"Valappil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-4518","authenticated-orcid":false,"given":"K","family":"Sikka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Thakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7905-3073","authenticated-orcid":false,"given":"H","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"S0022215123000348_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.02.021"},{"key":"S0022215123000348_ref5","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.1.120"},{"key":"S0022215123000348_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2014.12.006"},{"key":"S0022215123000348_ref4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117065"},{"key":"S0022215123000348_ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2001-011441"},{"key":"S0022215123000348_ref3","first-page":"1610","article-title":"Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion","volume":"76","author":"Blum","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"S0022215123000348_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08655-5"},{"key":"S0022215123000348_ref7","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5672"},{"key":"S0022215123000348_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9026-x"},{"key":"S0022215123000348_ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-2-352"},{"key":"S0022215123000348_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-5-22"},{"key":"S0022215123000348_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027563.44593.CC"},{"key":"S0022215123000348_ref2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200709-155MG"},{"key":"S0022215123000348_ref8","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03516"},{"key":"S0022215123000348_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.2.277"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215123000348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T14:51:45Z","timestamp":1699282305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215123000348\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0022215123000348"],"URL":"https:\/\/doi.org\/10.1017\/s0022215123000348","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"type":"print","value":"0022-2151"},{"type":"electronic","value":"1748-5460"}],"subject":[],"published":{"date-parts":[[2023,3,6]]}}}