{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:15:05Z","timestamp":1772565305318,"version":"3.50.1"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215123001512_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of combination therapy with and without batroxobin, and the frequency of batroxobin use on the prognosis of profound sudden sensorineural hearing loss.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123001512_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Hearing recovery in the batroxobin group (231 patients) and non-batroxobin group (56 patients) was compared. The correlation between the number of times batroxobin was used and hearing recovery was analysed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123001512_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The decrease in hearing threshold and overall improvement rate in the batroxobin group with hearing loss exceeding 100 dB HL was significantly higher than that in the non-batroxobin group. There was no linear correlation between the number of times batroxobin was used and the overall improvement rate. Using batroxobin two to three times achieved a therapeutic effectiveness plateau.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123001512_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Batroxobin can improve the efficacy of combination therapy for profound sudden sensorineural hearing loss exceeding 100 dB HL, and using batroxobin two to three times yields the maximum overall improvement rate.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215123001512","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T05:57:04Z","timestamp":1693461424000},"page":"270-275","source":"Crossref","is-referenced-by-count":7,"title":["Batroxobin can improve the efficacy of combination therapy for profound sudden sensorineural hearing loss greater than but not less than 100 dB HL"],"prefix":"10.1017","volume":"138","author":[{"given":"Li Zhu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3313-0990","authenticated-orcid":false,"given":"Wen Qi","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"S0022215123001512_ref1","first-page":"S1","article-title":"Clinical Practice Guideline: sudden hearing loss (update)","volume":"161","author":"Chandrasekhar","year":"2019","journal-title":"Otolaryngol Head Neck Surg"},{"key":"S0022215123001512_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328040c0f2"},{"key":"S0022215123001512_ref13","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309126213"},{"key":"S0022215123001512_ref4","first-page":"379","article-title":"Multi-center study on the treatment of sudden total deafness [in Chinese]","volume":"48","author":"Zheng","year":"2013","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"S0022215123001512_ref5","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2012.705904"},{"key":"S0022215123001512_ref15","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273721"},{"key":"S0022215123001512_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609347903"},{"key":"S0022215123001512_ref18","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209137500"},{"key":"S0022215123001512_ref3","first-page":"355","article-title":"Prospective clinical multi-center study on the treatment of sudden deafness with different typings in China [in Chinese]","volume":"48","year":"2013","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"S0022215123001512_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860180063031"},{"key":"S0022215123001512_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.01.001"},{"key":"S0022215123001512_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1534734613493291"},{"key":"S0022215123001512_ref20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00021.x"},{"key":"S0022215123001512_ref14","doi-asserted-by":"publisher","DOI":"10.1080\/0036554021000028082"},{"key":"S0022215123001512_ref2","first-page":"443","article-title":"Guideline of diagnosis and treatment of sudden deafness (2015) [in Chinese]","volume":"50","year":"2015","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"S0022215123001512_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2011.08.006"},{"key":"S0022215123001512_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-018-1718-y"},{"key":"S0022215123001512_ref11","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1104723"},{"key":"S0022215123001512_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(03)00189-9"},{"key":"S0022215123001512_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/000348945706600223"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215123001512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T09:40:42Z","timestamp":1708076442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215123001512\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0022215123001512"],"URL":"https:\/\/doi.org\/10.1017\/s0022215123001512","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,31]]}}}