{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:56:50Z","timestamp":1773219410813,"version":"3.50.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215123001652_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the functional magnetic resonance imaging changes in the olfactory structures of coronavirus disease 2019 patients experiencing olfactory dysfunction.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123001652_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This study included patients aged 25\u201365 years who presented with a sudden loss of smell, confirmed coronavirus disease 2019 infection, and persistent olfactory dysfunction for a minimum of 2 months without any treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123001652_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Irrespective of the side of brain activation, the analysis of the cumulative maximum diameter of the activation zones revealed significantly lower activation in the upper frontal lobe (<jats:italic>p<\/jats:italic> = 0.037) and basal ganglia (<jats:italic>p<\/jats:italic> = 0.023) in olfactory dysfunction patients. Irrespective of the side of activation, the analysis of the number of activation points demonstrated significantly lower activation in the upper frontal lobe (<jats:italic>p<\/jats:italic> = 0.036) and basal ganglia (<jats:italic>p<\/jats:italic> = 0.009) in olfactory dysfunction patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123001652_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Patients with coronavirus-triggered olfactory dysfunction exhibited lower activity in their basal ganglia and upper frontal lobe.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215123001652","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:49:03Z","timestamp":1696502943000},"page":"178-183","source":"Crossref","is-referenced-by-count":5,"title":["Functional magnetic resonance imaging in coronavirus disease 2019 induced olfactory 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