{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:53:08Z","timestamp":1794005588855,"version":"4.8.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215123002177_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To review the literature comparing functional endoscopic sinus surgery to dupilumab for the treatment of chronic rhinosinusitis with nasal polyps, in terms of symptom control, cost-effectiveness and complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123002177_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>A literature review was conducted using PubMed, ScienceDirect and Cochrane databases. Data were extracted manually.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123002177_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of six papers relevant to the main objective were found.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215123002177_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps has a significant impact on patients\u2019 quality of life. Both functional endoscopic sinus surgery and dupilumab achieve comparable disease control and result in good symptom relief. Dupilumab is far more expensive than functional endoscopic sinus surgery and is not considered cost-effective for the time being. This is expected to change after 10 years when the drug patent expires. More research is needed to compare the complications of both treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215123002177","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T01:20:57Z","timestamp":1700702457000},"page":"361-366","source":"Crossref","is-referenced-by-count":8,"title":["Biologics versus functional endoscopic sinus surgery for the treatment of chronic rhinosinusitis with nasal polyps: a literature review"],"prefix":"10.1017","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4118-7493","authenticated-orcid":false,"given":"Asmaa","family":"Alshatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"S0022215123002177_ref21","doi-asserted-by":"crossref","first-page":"e006680","DOI":"10.1136\/bmjopen-2014-006680","article-title":"The burden of revision sinonasal surgery in the UK--data from the Chronic Rhinosinusitis Epidemiology Study (CRES): a cross-sectional study","volume":"5","author":"Philpott","year":"2015","journal-title":"BMJ Open"},{"key":"S0022215123002177_ref8","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.158.8.3902","article-title":"Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia","volume":"158","author":"Simon","year":"1997","journal-title":"J Immunol"},{"key":"S0022215123002177_ref38","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jaip.2021.09.037","article-title":"Olfactory outcomes with dupilumab in chronic rhinosinusitis with nasal polyps","volume":"10","author":"Mullol","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"S0022215123002177_ref3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaip.2016.04.012","article-title":"Chronic rhinosinusitis with nasal polyps","volume":"4","author":"Stevens","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"S0022215123002177_ref9","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1021\/acs.jproteome.6b00367","article-title":"Activation of human peripheral blood eosinophils by cytokines in a comparative time-course proteomic\/phosphoproteomic study","volume":"16","author":"Soman","year":"2017","journal-title":"J Proteome Res"},{"key":"S0022215123002177_ref6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/19458924221149003","article-title":"Endotyping chronic rhinosinusitis with nasal polyps: understanding inflammation beyond phenotypes","volume":"37","author":"Chen","year":"2023","journal-title":"Am J Rhinol Allergy"},{"key":"S0022215123002177_ref32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/lary.24401","article-title":"Complications of primary and revision functional endoscopic sinus surgery for chronic rhinosinusitis","volume":"124","author":"Krings","year":"2014","journal-title":"Laryngoscope"},{"key":"S0022215123002177_ref31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/all.15134","article-title":"Real-life observational cohort verifies high efficacy of dupilumab for chronic rhinosinusitis with nasal polyps","volume":"77","author":"van der Lans","year":"2022","journal-title":"Allergy"},{"key":"S0022215123002177_ref39","first-page":"e7565","article-title":"Dupilumab for atopic dermatitis: the silver bullet we have been searching for?","volume":"12","author":"Tameez Ud Din","year":"2020","journal-title":"Cureus"},{"key":"S0022215123002177_ref14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4049\/jimmunol.169.1.443","article-title":"New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-251","volume":"169","author":"Hurst","year":"2002","journal-title":"J Immunol"},{"key":"S0022215123002177_ref1","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.3390\/jcm9072285","article-title":"Chronic rhinosinusitis--an update on epidemiology, pathogenesis and management","volume":"9","author":"Albu","year":"2020","journal-title":"J Clin Med"},{"key":"S0022215123002177_ref33","unstructured":"33 Sanofi. 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