{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:32:03Z","timestamp":1789425123922,"version":"build-2803163510"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To determine oncological and functional outcomes in patients with T3 and T4 laryngeal carcinoma, in which choice of treatment was based on expected laryngeal function and not T classification.<\/jats:p><\/jats:sec>Methods<\/jats:title>Oncological outcomes (disease-specific survival and overall survival) as well as functional outcomes (larynx preservation and functional larynx preservation) were analysed.<\/jats:p><\/jats:sec>Results<\/jats:title>In 130 T3 and 59 T4 patients, there was no difference in disease-specific survival or overall survival rates after radiotherapy (RT) (107 patients), chemoradiotherapy (36 patients) and total laryngectomy (46 patients). The five-year disease-specific survival rates were 83 per cent after RT, 78 per cent after chemoradiotherapy and 69 per cent after total laryngectomy, whereas overall survival rates were 62, 54 and 60 per cent, respectively. Five-year larynx preservation and functional larynx preservation rates were comparable for RT (79 and 66 per cent, respectively) and chemoradiotherapy (86 and 62 per cent, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>There is no difference in oncological outcome after (chemo)radiotherapy or total laryngectomy in T3 and T4 laryngeal carcinoma patients whose choice of treatment was based on expected laryngeal function.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215124000112","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T09:58:05Z","timestamp":1705571885000},"page":"672-678","source":"Crossref","is-referenced-by-count":5,"title":["Oncological and functional outcomes in T3 and T4 laryngeal cancer patients: choice for larynx preservation or total laryngectomy based on expected laryngeal function"],"prefix":"10.1017","volume":"138","author":[{"given":"Arman","family":"Nobacht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke W H","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoukje F","family":"Oosting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"van der Vegt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy B","family":"Halmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8631-7727","authenticated-orcid":false,"given":"Boudewijn E C","family":"Plaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"S0022215124000112_ref18","first-page":"1247","article-title":"Trends in treatment and survival for advanced laryngeal cancer: a 20-year population-based study in the Netherlands","volume":"38","author":"Timmermans","year":"2015","journal-title":"Head Neck"},{"key":"S0022215124000112_ref20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"key":"S0022215124000112_ref11","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/bjc.2011.92","article-title":"Impact of multidisciplinary team management in head and neck cancer patients","volume":"104","author":"Friedland","year":"2011","journal-title":"Br J Cancer"},{"key":"S0022215124000112_ref14","first-page":"56","article-title":"Primary total laryngectomy versus organ preservation for T3\/T4A laryngeal cancer: a population-based analysis of survival","volume":"41","author":"Dziegielewski","year":"2012","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"S0022215124000112_ref13","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.ijrobp.2015.03.004","article-title":"Total laryngectomy versus larynx preservation for T4a larynx cancer: patterns of care and survival outcomes","volume":"92","author":"Grover","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"S0022215124000112_ref10","first-page":"1","article-title":"Effects of multidisciplinary team care on the survival of patients with different stages of non-small cell lung cancer: a national cohort study","volume":"10","author":"Pan","year":"2015","journal-title":"PLoS One"},{"key":"S0022215124000112_ref7","first-page":"1","article-title":"Efficacy comparison between primary total laryngectomy and nonsurgical organ-preservation strategies in treatment of advanced stage laryngeal cancer a meta-analysis","volume":"97","author":"Tang","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"S0022215124000112_ref15","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1007\/s00405-017-4639-z","article-title":"Modifications in the treatment of advanced laryngeal cancer throughout the last 30 years","volume":"274","author":"Garc\u00eda Lorenzo","year":"2017","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"S0022215124000112_ref12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11912-020-00952-5","article-title":"Value and quality of care in head and neck oncology","volume":"22","author":"Takes","year":"2020","journal-title":"Curr Oncol Rep"},{"key":"S0022215124000112_ref9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.critrevonc.2006.07.005","article-title":"Quality of life research in head and neck cancer: a review of the current state of the science","volume":"62","author":"Murphy","year":"2007","journal-title":"Crit Rev Oncol Hematol"},{"key":"S0022215124000112_ref3","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archoto.2011.171","article-title":"Temporal trends in the treatment of early-and advanced-stage laryngeal cancer in the United States, 1985\u20132007","volume":"137","author":"Chen","year":"2011","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"S0022215124000112_ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.anl.2016.06.005","article-title":"Organ preservation with chemoradiation in advanced laryngeal cancer: the problem of generalizing results from randomized controlled trials","volume":"44","author":"Sanabria","year":"2017","journal-title":"Auris Nasus Larynx"},{"key":"S0022215124000112_ref4","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1002\/cncr.32292","article-title":"Comparing surgical and nonsurgical larynx-preserving treatments with total laryngectomy for locally advanced laryngeal cancer","volume":"125","author":"Patel","year":"2019","journal-title":"Cancer"},{"key":"S0022215124000112_ref17","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/archotol.124.9.964","article-title":"Long-term quality of life after treatment of laryngeal cancer","volume":"124","author":"Terrell","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"S0022215124000112_ref5","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1200\/JCO.2017.75.7385","article-title":"Use of larynx-preservation strategies in the treatment of laryngeal cancer: American Society of Clinical Oncology clinical practice guideline update","volume":"36","author":"Forastiere","year":"2018","journal-title":"J Clin Oncol"},{"key":"S0022215124000112_ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fonc.2019.00625","article-title":"Laryngeal preservation approaches: considerations for new selection criteria based on the DELOS-II trial","volume":"9","author":"Dietz","year":"2019","journal-title":"Front Oncol"},{"key":"S0022215124000112_ref6","author":"Haddad","year":"2022","journal-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Guideline Head and Neck Cancers"},{"key":"S0022215124000112_ref8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0360-3016(02)04613-8","article-title":"Second primary cancers in patients with laryngeal cancer: a population-based study","volume":"56","author":"Gao","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"S0022215124000112_ref1","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1200\/JCO.2015.61.2978","article-title":"Organ preservation for advanced larynx cancer: issues and outcomes","volume":"33","author":"Forastiere","year":"2015","journal-title":"J Clin Oncol"},{"key":"S0022215124000112_ref19","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/cncr.29241","article-title":"Long-term outcomes after surgical or nonsurgical initial therapy for patients with T4 squamous cell carcinoma of the larynx: a 3-decade survey","volume":"121","author":"Rosenthal","year":"2015","journal-title":"Cancer"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215124000112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T12:16:34Z","timestamp":1715688994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215124000112\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S0022215124000112"],"URL":"https:\/\/doi.org\/10.1017\/s0022215124000112","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,18]]}}}