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Otol."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215124000343_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to form astute deductions regarding the presentation, treatment and mortality of otogenic brain complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215124000343_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A systematic literature search of four medical databases (PubMed, Embase, Web of Science and Scopus) was conducted. Studies associated with otogenic brain complications were considered eligible. Fixed- and random-effects model meta-analysis was developed to assess the proportion estimate for each outcome individually.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215124000343_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Twenty-eight studies, with 1650 patients in total, were included. In 66 per cent of patients there was a known history of chronic otitis media. The most common symptoms were purulent otorrhoea (84 per cent), headache (65 per cent) and otalgia (45 per cent). A brain abscess was observed in 49 per cent of patients, followed by meningitis (34 per cent) and sinus thrombosis (22 per cent). A combination of surgical and conservative therapy was chosen in 84.3 per cent of cases and the mortality rate approached 11.1 per cent.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215124000343_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Otogenic brain complications are a possibly life-threatening condition. 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