{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:16:50Z","timestamp":1792088210630,"version":"4.4.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215124000562_sec_a1\"><jats:title>Objective<\/jats:title><jats:p>To determine if systemic administration of low-molecular-weight heparin impacts venous compromise in loco-regional flap reconstruction for head and neck subsites.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215124000562_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This prospective study was conducted on patients who had developed features of venous compromise of the flap. The case group received low-molecular-weight heparin (dalteparin).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215124000562_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Of the 73 patients who developed venous congestion, low-molecular-weight heparin was administered in 47 patients. In the low-molecular-weight heparin subset, 23 patients had either reversal or non-progression of venous compromise (48.9 per cent). Of the patients who had no response to low-molecular-weight heparin rescue, complete necrosis was seen in 4 and partial flap necrosis was observed in 19. The corresponding numbers in the control group were 13 and 12, respectively (odds ratio 23.9, <jats:italic>p<\/jats:italic> = 0.002). Additionally, the low-molecular-weight heparin arm had a lower incidence of partial or complete flap necrosis (<jats:italic>p<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215124000562_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Low-molecular-weight heparin salvage, when instituted early, is likely to result in a significant reduction in flap-related morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215124000562","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T08:41:24Z","timestamp":1712824884000},"page":"852-857","source":"Crossref","is-referenced-by-count":2,"title":["Low-molecular-weight heparin salvage in pedicled flap reconstruction in head and neck: a prospective cohort 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