{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:05:15Z","timestamp":1761005115208,"version":"build-2065373602"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215125000313_sec1a\"><jats:title>Objectives<\/jats:title><jats:p>This study evaluates the effectiveness of long-term, low-dose antibiotic treatment (macrolides and doxycycline) combined with intra-nasal corticosteroids in patients with chronic rhinosinusitis with nasal polyps.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215125000313_sec2b\"><jats:title>Methods<\/jats:title><jats:p>A total of 72 patients diagnosed with chronic rhinosinusitis with nasal polyps, aged 18\u201365, were followed for at least six months. Patients were randomized into three treatment groups: group 1 (intra-nasal corticosteroids and nasal saline irrigation), group 2 (intra-nasal corticosteroids, saline irrigation and macrolides) and group 3 (intra-nasal corticosteroids, saline irrigation and doxycycline).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215125000313_sec3c\"><jats:title>Results<\/jats:title><jats:p>Of the 72 patients, 43 (59.7 per cent) were male, and 29 (40.3 per cent) were female, with an average age of 48.69 plus or minus 15.71 years. A significant reduction in polyp stages was observed bilaterally and unilaterally in group 3 (<jats:italic>p<\/jats:italic> &lt; 0.05). Lund\u2013Mackay Score showed significant improvement in group 2 and group 3.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215125000313_sec4d\"><jats:title>Conclusion<\/jats:title><jats:p>Adding doxycycline to intra-nasal corticosteroids therapy led to significant reductions in polyp stages and Lund\u2013Mackay Score, suggesting potential clinical and radiological benefits.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215125000313","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T05:59:17Z","timestamp":1743400757000},"page":"816-819","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of long-term low-dose antibiotic therapy as an adjunct to intra-nasal corticosteroids in the management of chronic rhinosinusitis with nasal polyps"],"prefix":"10.1017","volume":"139","author":[{"given":"Fatma","family":"Y\u0131ld\u0131r\u0131m","sequence":"first","affiliation":[{"name":"Ayd\u0131n Adnan Menderes University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-4475","authenticated-orcid":false,"given":"Ergin","family":"Eroglu","sequence":"additional","affiliation":[{"name":"Hacettepe University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Basak","sequence":"additional","affiliation":[{"name":"Ayd\u0131n Adnan Menderes University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"S0022215125000313_ref14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1177\/000348940010900508","article-title":"Effects of clarithromycin on rheological properties of nasal mucus in patients with chronic sinusitis","volume":"109","author":"Rhee","year":"2000","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"S0022215125000313_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21064"},{"key":"S0022215125000313_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1993.tb00628.x"},{"key":"S0022215125000313_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2019.12.005"},{"key":"S0022215125000313_ref2","unstructured":"2 \u00dcnal, OF , Nasal polyp, \u00d6nerci M. . 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