{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T04:58:49Z","timestamp":1771736329430,"version":"3.50.1"},"reference-count":54,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215125102727_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study is to systematically review and analyse the literature regarding clinical application of picrotoxin for vertigo caused by peripheral vestibular disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125102727_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a search in PubMed\/MEDLINE and Google Scholar in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses recommendations. The primary selection included all studies exploring the effect of this phytopharmacological substance on the vestibular system and vertigo. The secondary selection included only reports on its clinical use for treatment of M\u00e9ni\u00e8re\u2019s disease and other peripheral vestibular disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125102727_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From the 398 identified studies, 18 were included from the primary selection and 6 from the secondary selection. In total, 203 patients received picrotoxin; 85 of them were treated for vertigo with 1-mg picrotoxin suppositories. In this subgroup vertigo was reduced in 74.9 per cent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125102727_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Picrotoxin is a non-invasive treatment option worth considering, especially in cochlear-implanted patients with recurring disabling vertigo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215125102727","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T07:25:29Z","timestamp":1752477929000},"page":"1021-1027","source":"Crossref","is-referenced-by-count":0,"title":["Picrotoxin for vertigo control in M\u00e9ni\u00e8re\u2019s disease and other peripheral vestibular disorders: a systematic review"],"prefix":"10.1017","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-2081","authenticated-orcid":false,"given":"Stefan","family":"Lyutenski","sequence":"first","affiliation":[{"name":"Helios Hospital Berlin-Buch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"James","sequence":"additional","affiliation":[{"name":"Helios Hospital Berlin-Buch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bloching","sequence":"additional","affiliation":[{"name":"Helios Hospital Berlin-Buch"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"S0022215125102727_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(89)90021-9"},{"key":"S0022215125102727_ref9","unstructured":"9 S2k-Leitlinie-Vestibul\u00e4re Funktionsst\u00f6rungen AWMF (Version 1.0). 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